• USA Home
  • I9660 - Anti-Integrin α2b (CD41) antibody, Mouse monoclonal

EMAIL THIS PAGE TO A FRIEND
I9660 Sigma

Anti-Integrin α2b (CD41) antibody, Mouse monoclonal

clone PM6/248, purified from hybridoma cell culture

Synonym: Anti-CD41, Anti-CD41B, Anti-GP2B, Anti-GTA, Anti-ITGA2B integrin, alpha 2b

Purchase

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
species reactivity   baboon, human
application(s)   flow cytometry: 1-2 μg/mL using human platelets
  immunoprecipitation: suitable
clone   PM6/248, monoclonal
concentration   ~1.0 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... ITGA2B(3674)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

human platelet membranes

General description

The gene ITGA2B (integrin subunit α 2b) encodes one of the 18 α subunits of integrins, which are transmembrane α/β heterodimers. The heterodimers, in mammals, are made up of a combination of one of 18 possible α subunits together with one of eight β subunits. The α and β subunits are type-I membrane proteins that contain a single transmembrane region linking a large extracellular domain and short noncatalytic cytoplasmic tail.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The heterodimer αIIbβ3 functions primarily in platelet aggregation, a crucial process in hemostasis and thrombosis. Integrin αIIbβ3, also referred to as glycoprotein IIbIIIa is a major adhesion receptor on platelets that is capable of binding to fibrinogen upon platelet stimulation. Defects in this gene have been associated with Glanzmann thrombasthenia, an autosomal recessive bleeding disorder.

Price and Availability


Antibody Explorer

Explore with Confidence
Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
Protocols & Articles

Related Content

Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?