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I9898 Sigma

Anti-Interleukin-5 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-IL-5

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Description

Immunogen

recombinant human IL expressed in Sf 21 insect cell line.

General description

The antibody neutralizes the biological activity of recombinant human IL-5.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Biochem/physiol Actions

Interleukin-5 is a T-cell derived cytokine that induces the differentiation of B cells into antibody producing plasma cells. It is a critical differentiation factor for eosinophils and regulates the expression of genes required for cell proliferation, survival and maturation. The cellular functions of IL-5 are mediated by JAK-STAT, Btk and Ras/Raf-ERK signaling pathways. IL-5 is a good molecular target for the treatment of eosinophilic diseases.

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Safety & Documentation

Documents

Certificate of Analysis

Certificate of Origin

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  2
Protocols & Articles

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Peer-Reviewed Papers
15

References

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