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I9898 Sigma

Anti-Interleukin-5 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym: Anti-IL-5

Description

Immunogen

recombinant human IL expressed in Sf 21 insect cell line.

General description

The antibody neutralizes the biological activity of recombinant human IL-5.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein G.

Biochem/physiol Actions

Interleukin-5 is a T-cell derived cytokine that induces the differentiation of B cells into antibody producing plasma cells. It is a critical differentiation factor for eosinophils and regulates the expression of genes required for cell proliferation, survival and maturation. The cellular functions of IL-5 are mediated by JAK-STAT, Btk and Ras/Raf-ERK signaling pathways. IL-5 is a good molecular target for the treatment of eosinophilic diseases.

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