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J104 Sigma

Anti-c-Jun antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Gene Regulation, Antibodies to Chromatin, Antibodies to Common Transcription Factors,
species reactivity   mouse
application(s)   western blot (chemiluminescent): 10 μg/mL using c-Jun expressed in serum stimulated mouse fibroblasts (NIH3T3)
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   mouse ... Jun(16476)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acid residues 91-105 of mouse c-Jun.

Physical form

Lyophilized, purified rabbit IgG, containing 0.05% sodium azide.

Application

Anti-c-Jun antibody produced in rabbit has been used as a primary antibody in immunohistochemistry.

Reconstitution

Reconstitute with 100 μL deionized water.

Biochem/physiol Actions

The protooncogene c-Jun encodes a member of the jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes.

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