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  • J3253 - Monoclonal Anti-Junctional Sarcoplasmic Reticulum Protein antibody produced in mouse

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J3253 Sigma

Monoclonal Anti-Junctional Sarcoplasmic Reticulum Protein antibody produced in mouse

clone VF1C, diluted ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Extracellular Matrix Proteins,
species reactivity   rat, guinea pig, canine, mouse, rabbit
application(s)   indirect immunofluorescence: suitable
  western blot: suitable
clone   VF1C, monoclonal
antibody form   diluted ascites fluid
mol wt   antigen mol wt 90 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Jsrp1(71912)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

rabbit skeletal muscle triads.

General description

The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1), also referred to as JP45, encodes an integral protein that contains a predicted cytoplasmic domain, an intralumenal domain that is rich in positively charged amino acids, preceded by a single transmembrane segment. The mRNA has been detected in 17-day-old mouse embryos, with increased expression during the second month of postnatal development. Its expression decreases 3-fold during aging. The protein is localized to the junctional sarcoplasmic reticulum.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide.

Biochem/physiol Actions

The gene Jsrp1 (junctional sarcoplasmic reticulum protein 1) encodes an integral protein component of the junctional face membrane of the skeletal muscle sarcoplasmic reticulum. It is found to associate with Cav1.1 (voltage-dependent Ca2+ channel) and calsequestrin, a luminal Ca2+-binding protein. The complex formed by Jsrp1 and Cav1.1 is found to be decreased with age and has been linked to decayed muscle strength and physical disability in the elderly. Knock-out of this gene in young mice results in decreased expression of Cav1.1 and diminished muscle strength.

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