Kaempferol

Papers

1. Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption Wattel, A., et al. Biochem. Pharmacol. 65, 35-42, (2003)

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2. Spectrophotometric determination of antimony with 3,5,7,4′-tetrahydroxyflavone (kaempferol) Garg, B.S., et al. Talanta 16, 462-464, (1969)

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3. 3,5,7,4′-Tetrahydroxyflavone (kaempferol) as a chromogenic reagent for gallium and indium Garg B.S., and Singh, R.P. Talanta 18, 761-766, (1971)

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4. Kaempferol-induced nuclear DNA damage and lipid peroxidation. Sahu, S.C. and Gray, G.C. Cancer Lett. 85, 159-164, (1994)

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5. Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. Boege, F., et al. J. Biol. Chem. 271, 2262-2270, (1996)

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Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. Lin, J.K., et al. J. Cell. Biochem. (Suppl.) 28-29, 39-48, (1997)

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Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine. Kuo, M.L., et al. Cancer Lett. 87, 91-97, (1994)

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Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study. Jean-Baptiste Daskiewicz et al J. Med. Chem. 48, 2790-804, (2005)

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Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. Alex N Bullock et al J. Med. Chem. 48, 7604-14, (2005)

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Expanding the ChemGPS chemical space with natural products. Josefin Larsson et al J. Nat. Prod. 68, 985-91, (2005)

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Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. Deniz Tasdemir et al J. Med. Chem. 49, 3345-53, (2006)

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Cytotoxic triterpenoids from the leaves of Microtropis fokienensis. I-Hsiao Chen et al J. Nat. Prod. 69, 1543-6, (2006)

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Simple criterion for selection of flavonoid compounds with anti-HIV activity. Veljko Veljkovic et al Bioorg. Med. Chem. Lett. 17, 1226-32, (2007)

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Potent anti-obese principle from Rosa canina: structural requirements and mode of action of trans-tiliroside. Kiyofumi Ninomiya et al Bioorg. Med. Chem. Lett. 17, 3059-64, (2007)

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Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Andrei I Khlebnikov et al Bioorg. Med. Chem. 15, 1749-70, (2007)

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Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Robert D Bruno et al Bioorg. Med. Chem. 15, 5047-60, (2007)

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Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase. Sheldon Holder et al Bioorg. Med. Chem. 15, 6463-73, (2007)

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Inhibitors of osteoclast differentiation from Cephalotaxus koreana. Kee Dong Yoon et al J. Nat. Prod. 70, 2029-32, (2007)

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Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti Deng, S., et al. J. Nat. Prod. 70, 859-862, (2007)

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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Gavin J Williams et al Nat. Chem. Biol. 3, 657-62, (2007)

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Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase. Elena Lo Piparo et al J. Med. Chem. 51, 3555-61, (2008)

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Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. Daniela Schuster et al J. Med. Chem. 51, 4188-99, (2008)

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The effect of flavonoid derivatives on doxorubicin transport and metabolism. Radka Václavíková et al Bioorg. Med. Chem. 16, 2034-42, (2008)

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Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Ryoko Takasawa et al Bioorg. Med. Chem. 16, 3969-75, (2008)

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Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Ai-Lin Liu et al Bioorg. Med. Chem. 16, 7141-7, (2008)

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Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Teresa Tarragó et al Bioorg. Med. Chem. 16, 7516-24, (2008)

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QSAR modeling of the interaction of flavonoids with GABA(A) receptor. Pablo R Duchowicz et al Eur. J. Med. Chem. 43, 1593-602, (2008)

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Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. Nam Hee Yoo et al J. Nat. Prod. 71, 713-5, (2008)

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Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation. Markus Trunzer et al J. Med. Chem. 52, 329-35, (2009)

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Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. Iris L K Wong et al J. Med. Chem. 52, 5311-22, (2009)

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7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. Azadeh Matin et al J. Med. Chem. 52, 6835-50, (2009)

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Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Yosuke Nishizaki et al Bioorg. Med. Chem. Lett. 19, 4706-10, (2009)

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A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Ashley A Reinke et al Bioorg. Med. Chem. Lett. 19, 4952-7, (2009)

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Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3. Tomohiro Itoh et al Bioorg. Med. Chem. 17, 5374-9, (2009)

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Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells. Hisashi Matsuda et al Bioorg. Med. Chem. 17, 6048-53, (2009)

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Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Hyung Jae Jeong et al Bioorg. Med. Chem. 17, 6816-23, (2009)

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QSAR study of antioxidant activity of wine polyphenols. Vesna Rastija et al Eur. J. Med. Chem. 44, 400-8, (2009)

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Antileishmaniasis activity of flavonoids from Consolida oliveriana. Clotilde Marín et al J. Nat. Prod. 72, 1069-74, (2009)

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The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells. Vasilis P Androutsopoulos et al J. Nat. Prod. 72, 1390-4, (2009)

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Small-molecule inhibitors of NADPH oxidase 4. Gábor Borbély et al J. Med. Chem. 53, 6758-62, (2010)

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Relationships between structures of hydroxyflavones and their antioxidative effects. Jiye Hyun et al Bioorg. Med. Chem. Lett. 20, 5510-3, (2010)

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The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells. Do Thi Ha et al Bioorg. Med. Chem. Lett. 20, 6076-81, (2010)

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Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea. Chia-Lin Lee et al Bioorg. Med. Chem. Lett. 20, 7354-7, (2010)

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Changes in flavonoid content and tyrosinase inhibitory activity in kenaf leaf extract after far-infrared treatment. Ho Sik Rho et al Bioorg. Med. Chem. Lett. 20, 7534-6, (2010)

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Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes. Hiroko Tani et al Bioorg. Med. Chem. 18, 151-7, (2010)

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Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase. Shingo Arioka et al Bioorg. Med. Chem. 18, 1633-40, (2010)

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Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation. John A Carver et al Bioorg. Med. Chem. 18, 222-8, (2010)

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Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Souichi Nakashima et al Bioorg. Med. Chem. 18, 2337-45, (2010)

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Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids. Dragan Ami? et al Bioorg. Med. Chem. 18, 28-35, (2010)

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Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Hitomi Takemura et al Bioorg. Med. Chem. 18, 6310-5, (2010)

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QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors. Andrew G Mercader et al Eur. J. Med. Chem. 45, 1724-30, (2010)

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Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase. Maja Katalini? et al Eur. J. Med. Chem. 45, 186-92, (2010)

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Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation. P Basabe et al Eur. J. Med. Chem. 45, 4258-69, (2010)

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Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98. Eduardo Borges de Melo et al Eur. J. Med. Chem. 45, 4562-9, (2010)

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A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-? in activated RAW 264.7 cells. Nguyen Xuan Nhiem et al Bioorg. Med. Chem. Lett. 21, 1777-81, (2011)

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Synthesis and antioxygenic activities of seabuckthorn flavone-3-ols and analogs. N Pandurangan et al Bioorg. Med. Chem. Lett. 21, 5328-30, (2011)

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In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. Petra H Pfisterer et al Bioorg. Med. Chem. 19, 1002-9, (2011)

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Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). Anne Pick et al Bioorg. Med. Chem. 19, 2090-102, (2011)

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Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. Hisashi Matsuda et al Bioorg. Med. Chem. 19, 2835-41, (2011)

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Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Vasilis P Androutsopoulos et al Bioorg. Med. Chem. 19, 2842-9, (2011)

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Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. Gugan Kothandan et al Eur. J. Med. Chem. 46, 4078-88, (2011)

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Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso. Jean J K Bankeu et al J. Nat. Prod. 74, 1370-8, (2011)

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Discovery of estrogen receptor ? modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Li Liu et al Bioorg. Med. Chem. Lett. 22, 154-63, (2012)

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Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase. Sadaf Naeem et al Bioorg. Med. Chem. 20, 1251-8, (2012)

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Merck 14,5274

Beil. 18,V,5,251