|Related Categories||Antioxidant and Free Radical Scavengers, Bioactive Small Molecules, Biochemicals and Reagents, Bioflavonoids, Cancer Metabolism,|
|storage condition||protect from light|
|solubility||ethanol: soluble20 mg/mL|
|DMSO: soluble50 mg/mL|
|storage temp.||room temp|
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)|
mouse ... Hexa(15211)
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1
Bottomless glass bottle. Contents are inside inserted fused cone.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P281-P301 + P310|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25-68|
|Safety Statements (Europe)||36/37-45|
|RIDADR||UN 2811 6.1 / PGIII|
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations
Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. Lin, J.K., et al. J. Cell. Biochem. (Suppl.) 28-29, 39-48, (1997)
Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Luo H, Rankin GO, Liu L, et al. Nutr. Cancer 61(4), 554-63, (2009)
Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. Kanazirska MV, Fuchs PM, Chen L, et al. Curr. Pharm. Biotechnol. 13(15), 2761-7, (2012)
Comparison of effectiveness in antitumor activity between flavonoids and polyphenols of the methanolic extract of roots of Potentilla fulgens in breast cancer cells. Radhika M, Ghoshal N, and Chatterjee A J. Complement. Integr. Med. 9, Article 24, (2012)
Inhibitory effect of Ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism. Wang SD, Xie ZQ, Chen J, et al. J. Dig. Dis. 13(10), 525-35, (2012)
Decavanadate, decaniobate, tungstate and molybdate interactions with sarcoplasmic reticulum Ca(2+)-ATPase: quercetin prevents cysteine oxidation by vanadate but does not reverse ATPase inhibition. Fraqueza G, Batista de Carvalho LA, Marques MP, et al. Dalton Trans. 41(41), 12749-58, (2012)
In vivo efficacy studies of layer-by-layer nano-matrix bearing kaempferol for the conditions of osteoporosis: a study in ovariectomized rat model. Kumar A, Gupta GK, Khedgikar V, et al. Eur. J. Pharm. Biopharm. 82(3), 508-17, (2012)
Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Annab LA, Bortner CD, Sifre MI, et al. Differentiation 84(4), 330-43, (2012)
Bioavailability study of a polyphenol-enriched extract from Hibiscus sabdariffa in rats and associated antioxidant status. Fernández-Arroyo S, Herranz-López M, Beltrán-Debón R, et al. Mol. Nutr. Food. Res. 56(10), 1590-5, (2012)
Kaempferol-human serum albumin interaction: characterization of the induced chirality upon binding by experimental circular dichroism and TDDFT calculations. Matei I, Ionescu S, and Hillebrand M Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96, 709-15, (2012)
The flavonoid content and antiproliferative, hypoglycaemic, anti-inflammatory and free radical scavenging activities of Annona dioica St. Hill. Formagio AS, Kassuya CA, Neto FF, et al. BMC Complement Altern. Med. 13, 14, (2013)
In vivo investigation on the potential of galangin, kaempferol and myricetin for protection of D-galactose-induced cognitive impairment. Lei Y, Chen J, Zhang W, et al. Food Chem. 135(4), 2702-7, (2012)
Bioavailability of quercetin from its aglycone and its glucorhamnoside rutin in lactating dairy cows after intraduodenal administration. Gohlke A, Ingelmann CJ, Nürnberg G, et al. J. Dairy Sci. 96(4), 2303-13, (2013)
Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Andrei I Khlebnikov et al Bioorg. Med. Chem. 15, 1749-70, (2007)
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. Azadeh Matin et al J. Med. Chem. 52, 6835-50, (2009)
The selected flavonol glycoside derived from Sophorae Flos improves glucose uptake and inhibits adipocyte differentiation via activation AMPK in 3T3-L1 cells. Do Thi Ha et al Bioorg. Med. Chem. Lett. 20, 6076-81, (2010)
A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-? in activated RAW 264.7 cells. Nguyen Xuan Nhiem et al Bioorg. Med. Chem. Lett. 21, 1777-81, (2011)
In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. Petra H Pfisterer et al Bioorg. Med. Chem. 19, 1002-9, (2011)
Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain. Gugan Kothandan et al Eur. J. Med. Chem. 46, 4078-88, (2011)
Discovery of estrogen receptor ? modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Li Liu et al Bioorg. Med. Chem. Lett. 22, 154-63, (2012)
Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase. Sadaf Naeem et al Bioorg. Med. Chem. 20, 1251-8, (2012)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?