Ketoconazole

Papers

1. Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey. Keith W. Ward, Gary J. Stelman, et al. Drug Metab. Dispos. 32, 172, (2004)

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2. Potentiation of Interleukin 1 Mediated Antitumor Effects by Ketoconazole Paul G. Braunschweiger, Nirmal Kumar, et al. Cancer Res. 50, 4709-4717, (1990)

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3. Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake- inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo LL von Moltke, DJ Greenblatt, et al. J. Pharmacol. Exp. Ther. 268, 1278, (1994)

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Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology. Von Moltke, L.L., et al. Clin. Pharmacokinet. 29 (Suppl 1), 33, (1995)

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Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Eagling, V.A., et al. Br. J. Clin. Pharmacol. 45, 107, (1998)

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Oxidation of nonionic detergents by cytochrome P450 enzymes. Hosea, N.A., and Guengerich, F.P. Arch. Biochem. Biophys. 353, 365, (1998)

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Heterozygous Mutation Within A Kinase-conserved Motif Of The Insulin-like Growth Factor I Receptor Causes Intrauterine And Postnatal Growth Retardation. Kruis, T., et al. J. Clin. Endocrinol. Metab. 95, 1137-42, (2010)

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Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. Sarah Ulmschneider et al J. Med. Chem. 48, 1563-75, (2005)

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Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. Sarah Ulmschneider et al J. Med. Chem. 48, 1796-805, (2005)

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Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. Venkatesh D Handratta et al J. Med. Chem. 48, 2972-84, (2005)

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Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis. Marieke Voets et al J. Med. Chem. 48, 6632-42, (2005)

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Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays. Sook Wah Yee et al J. Med. Chem. 48, 7123-31, (2005)

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A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Motoi Tobita et al Bioorg. Med. Chem. Lett. 15, 2886-90, (2005)

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Steroidal saponins from Smilax medica and their antifungal activity. Marc Sautour et al J. Nat. Prod. 68, 1489-93, (2005)

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Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities. Flor Soriano-Agatón et al J. Nat. Prod. 68, 1581-7, (2005)

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Potent CYP3A4 inhibitory constituents of Piper cubeba. Tepy Usia et al J. Nat. Prod. 68, 64-8, (2005)

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Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Marieke Voets et al J. Med. Chem. 49, 2222-31, (2006)

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Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking C. Sheng, et al., J. Med. Chem. 49, 2512-2525, (2006)

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Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)). Caroline P Owen et al Bioorg. Med. Chem. Lett. 16, 4011-5, (2006)

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Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)). Chirag H Patel et al Bioorg. Med. Chem. Lett. 16, 4752-6, (2006)

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Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BK(Ca)). Eoin C Power et al Bioorg. Med. Chem. Lett. 16, 887-90, (2006)

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Novel endoperoxides: synthesis and activity against Candida species. Peter Macreadie et al Bioorg. Med. Chem. Lett. 16, 920-2, (2006)

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Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. Virginie Treyvaud Amiguet et al J. Nat. Prod. 69, 1005-9, (2006)

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Bioactive oligostilbenoids from the stem bark of Hopea exalata. Hui Ming Ge et al J. Nat. Prod. 69, 1800-2, (2006)

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Identifying off-target effects and hidden phenotypes of drugs in human cells. Marnie L MacDonald et al Nat. Chem. Biol. 2, 329-37, (2006)

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OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. Makoto Matsumoto et al PLoS Med. 3, e466, (2006)

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Synthesis and antifungal activities of novel 2-aminotetralin derivatives. Bin Yao et al J. Med. Chem. 50, 5293-300, (2007)

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In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. Williams Porcal et al J. Med. Chem. 50, 6004-15, (2007)

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Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4. Emre M Isin et al J. Biol. Chem. 282, 6863-74, (2007)

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Discovery of novel indazole-linked triazoles as antifungal agents. Joon Seok Park et al Bioorg. Med. Chem. Lett. 17, 3486-90, (2007)

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Synthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase. Takahiro Katoh et al Bioorg. Med. Chem. 15, 2736-48, (2007)

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Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships. Williams Porcal et al Bioorg. Med. Chem. 15, 2768-81, (2007)

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Design of endoperoxides with anti-Candida activity. Thomas D Avery et al Bioorg. Med. Chem. 15, 36-42, (2007)

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Synthesis and antifungal activity of (Z)-5-arylidenerhodanines. Maximiliano Sortino et al Bioorg. Med. Chem. 15, 484-94, (2007)

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Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide. Neslihan Ozbek et al Bioorg. Med. Chem. 15, 5105-9, (2007)

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Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. Naz M Aghatabay et al Eur. J. Med. Chem. 42, 1069-75, (2007)

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Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). Qing-Yan Sun et al Eur. J. Med. Chem. 42, 1226-33, (2007)

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Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. Naz M Aghatabay et al Eur. J. Med. Chem. 42, 205-13, (2007)

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Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. Lei Shi et al Eur. J. Med. Chem. 42, 558-64, (2007)

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Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Sang Hyun Cho et al Antimicrob. Agents Chemother. 51, 1380-5, (2007)

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A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. Shaoji Cheng et al Antimicrob. Agents Chemother. 51, 1855-8, (2007)

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In vitro susceptibility of Sporothrix schenckii to six antifungal agents determined using three different methods. Eidi Alvarado-Ramírez et al Antimicrob. Agents Chemother. 51, 2420-3, (2007)

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Role for cell density in antifungal drug resistance in Candida albicans biofilms. Palani Perumal et al Antimicrob. Agents Chemother. 51, 2454-63, (2007)

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In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. Nikolaos G Almyroudis et al Antimicrob. Agents Chemother. 51, 2587-90, (2007)

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Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants. Christoph Ruckenstuhl et al Antimicrob. Agents Chemother. 51, 275-84, (2007)

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Fosamprenavir plus ritonavir increases plasma ketoconazole and ritonavir exposure, while amprenavir exposure remains unchanged. Mary B Wire et al Antimicrob. Agents Chemother. 51, 2982-4, (2007)

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Cross-resistance to medical and agricultural azole drugs in yeasts from the oropharynx of human immunodeficiency virus patients and from environmental Bavarian vine grapes. Frank-Michael C Müller et al Antimicrob. Agents Chemother. 51, 3014-6, (2007)

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Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy. Albrecht Serfling et al Antimicrob. Agents Chemother. 51, 3672-6, (2007)

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The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole. Neeraj Chauhan et al Antimicrob. Agents Chemother. 51, 3747-51, (2007)

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Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity. Ruqaiyyah Siddiqui et al Antimicrob. Agents Chemother. 51, 4471-3, (2007)

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Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. Patrick Vandeputte et al Antimicrob. Agents Chemother. 51, 982-90, (2007)

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Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. Chung-Ren Su et al J. Nat. Prod. 70, 1930-3, (2007)

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Bioactive polychlorinated bibenzyls from the liverwort Riccardia polyclada. Cecilia Labbé et al J. Nat. Prod. 70, 2019-21, (2007)

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Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. Anja Krick et al J. Nat. Prod. 70, 353-60, (2007)

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High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections. Lixin Zhang et al Proc. Natl. Acad. Sci. U. S. A. 104, 4606-11, (2007)

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Chemical genetics reveals a complex functional ground state of neural stem cells Diamandis, P., et. al. Nat. Chem. Biol. 3(5), 268-273, (2007)

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Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. Dennis J Pelletier et al J. Chem. Inf. Model. 47, 1196-205, (2007)

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Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Sean Ekins et al Drug Metab. Dispos. 35, 493-500, (2007)

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Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases. Martin Frotscher et al J. Med. Chem. 51, 2158-69, (2008)

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New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues. Ilse M Zolle et al J. Med. Chem. 51, 2244-53, (2008)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)

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1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. Giuseppe La Regina et al J. Med. Chem. 51, 3841-55, (2008)

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Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. Mariano A E Pinto-Bazurco Mendieta et al J. Med. Chem. 51, 5009-18, (2008)

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Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. Ralf Heim et al J. Med. Chem. 51, 5064-74, (2008)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. Simon Lucas et al J. Med. Chem. 51, 6138-49, (2008)

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In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. Simon Lucas et al J. Med. Chem. 51, 8077-87, (2008)

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Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17. Mariano A E Pinto-Bazurco Mendieta et al Bioorg. Med. Chem. Lett. 18, 267-73, (2008)

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Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. Ping Liu et al Bioorg. Med. Chem. Lett. 18, 3261-5, (2008)

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Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bhaskar C Das et al Bioorg. Med. Chem. Lett. 18, 3974-7, (2008)

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Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure. Carsten Jagusch et al Bioorg. Med. Chem. 16, 1992-2010, (2008)

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Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51). Tina Korosec et al Bioorg. Med. Chem. 16, 209-21, (2008)

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N-Phenyl and N-phenylalkyl-maleimides acting against Candida spp.: time-to-kill, stability, interaction with maleamic acids. Maximiliano Sortino et al Bioorg. Med. Chem. 16, 560-8, (2008)

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Support vector machines classification of hERG liabilities based on atom types. Lei Jia et al Bioorg. Med. Chem. 16, 6252-60, (2008)

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New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle. Williams Porcal et al Bioorg. Med. Chem. 16, 6995-7004, (2008)

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Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge. Qingzhong Hu et al Bioorg. Med. Chem. 16, 7715-27, (2008)

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In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions. Carlos M Meléndez Gómez et al Bioorg. Med. Chem. 16, 7908-20, (2008)

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Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. Vladímir V Kouznetsov et al Bioorg. Med. Chem. 16, 794-809, (2008)

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NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds. Joerg Konter et al Bioorg. Med. Chem. 16, 8294-300, (2008)

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Screening of herbal constituents for aromatase inhibitory activity. S Paoletta et al Bioorg. Med. Chem. 16, 8466-70, (2008)

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Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. Li-Na Zhang et al Eur. J. Med. Chem. 43, 1543-51, (2008)

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New triazole and triazolothiadiazine derivatives as possible antimicrobial agents. Zafer Asim Kaplancikli et al Eur. J. Med. Chem. 43, 155-9, (2008)

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Enamines as novel antibacterials and their structure-activity relationships. Zhu-Ping Xiao et al Eur. J. Med. Chem. 43, 1828-36, (2008)

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Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid. Mohd Amir et al Eur. J. Med. Chem. 43, 2056-66, (2008)

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Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. Huan-Qiu Li et al Eur. J. Med. Chem. 43, 662-7, (2008)

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Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles. V Padmavathi et al Eur. J. Med. Chem. 43, 917-24, (2008)

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Reliability of the WIDERYST susceptibility testing system for detection of in vitro antifungal resistance in yeasts. Manuel Cuenca-Estrella et al Antimicrob. Agents Chemother. 52, 1062-5, (2008)

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In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum. Mónica Azor et al Antimicrob. Agents Chemother. 52, 2228-31, (2008)

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Potent in vitro antifungal activities of naturally occurring acetylenic acids. Xing-Cong Li et al Antimicrob. Agents Chemother. 52, 2442-8, (2008)

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Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms. C J Seneviratne et al Antimicrob. Agents Chemother. 52, 3259-66, (2008)

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Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement. Esther Castanys-Muñoz et al Antimicrob. Agents Chemother. 52, 3573-9, (2008)

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Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. J E Parker et al Antimicrob. Agents Chemother. 52, 3597-603, (2008)

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A nonsense mutation in the ERG6 gene leads to reduced susceptibility to polyenes in a clinical isolate of Candida glabrata. Patrick Vandeputte et al Antimicrob. Agents Chemother. 52, 3701-9, (2008)

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In vitro antifungal susceptibilities of five species of sporothrix. Rita Marimon et al Antimicrob. Agents Chemother. 52, 732-4, (2008)

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Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. Andrea Escalante et al J. Nat. Prod. 71, 1720-5, (2008)

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Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. Alexander Pontius et al J. Nat. Prod. 71, 1793-9, (2008)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxic. Mech. Methods 18, 217-27, (2008)

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Rational modification of a candidate cancer drug for use against Chagas disease. James M Kraus et al J. Med. Chem. 52, 1639-47, (2009)

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Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Ulrich Zachariae et al J. Med. Chem. 52, 4266-76, (2009)

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Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi. P C Leal et al Bioorg. Med. Chem. Lett. 19, 1793-6, (2009)

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Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. Xiaoyun Chai et al Bioorg. Med. Chem. Lett. 19, 1811-4, (2009)

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Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. James McNulty et al Bioorg. Med. Chem. Lett. 19, 3233-7, (2009)

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Regioselective synthesis and biological evaluation of bis(indolyl)methane derivatized 1,4-disubstituted 1,2,3-bistriazoles as anti-infective agents. M Damodiran et al Bioorg. Med. Chem. Lett. 19, 3611-4, (2009)

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Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen. W Edward Martucci et al Bioorg. Med. Chem. Lett. 19, 418-23, (2009)

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Synthesis and antimultidrug resistance evaluation of icariin and its derivatives. Liu, D.F. et al. Bioorg. Med. Chem. Lett. 19, 4237-4240, (2009)

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Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)). Sabbir Ahmed et al Bioorg. Med. Chem. Lett. 19, 4698-701, (2009)

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A novel class of highly potent multidrug resistance reversal agents: disubstituted adamantyl derivatives. Kyung Hoon Min et al Bioorg. Med. Chem. Lett. 19, 5376-9, (2009)

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Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4. James McNulty et al Bioorg. Med. Chem. Lett. 19, 5607-12, (2009)

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Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. Nilkanth G Aher et al Bioorg. Med. Chem. Lett. 19, 759-63, (2009)

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Bulky 1,4-benzoxazine derivatives with antifungal activity. Renata Fringuelli et al Bioorg. Med. Chem. 17, 3838-46, (2009)

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Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates. Nelilma C Romeiro et al Bioorg. Med. Chem. 17, 641-52, (2009)

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5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. Alejandra Gerpe et al Bioorg. Med. Chem. 17, 7500-9, (2009)

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Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis. Delphine Renard et al Bioorg. Med. Chem. 17, 8123-37, (2009)

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New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines. A B A el-Gazzar et al Eur. J. Med. Chem. 44, 1427-36, (2009)

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Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. Xiaoyun Chai et al Eur. J. Med. Chem. 44, 1913-20, (2009)

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Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. Frederico L Gouveia et al Eur. J. Med. Chem. 44, 2038-43, (2009)

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Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles. V Padmavathi et al Eur. J. Med. Chem. 44, 2106-12, (2009)

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Penetratin and derivatives acting as antifungal agents. Marcelo F Masman et al Eur. J. Med. Chem. 44, 212-28, (2009)

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Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives. Afshin Fassihi et al Eur. J. Med. Chem. 44, 2145-57, (2009)

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Synthesis and bioassay of a new class of heterocycles pyrrolyl oxadiazoles/thiadiazoles/triazoles. V Padmavathi et al Eur. J. Med. Chem. 44, 2313-21, (2009)

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Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8-dibromo-2-phenylquinazolin-4(3H)-ones. Perumal Panneerselvam et al Eur. J. Med. Chem. 44, 2328-33, (2009)

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Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. Ulrike E Hille et al Eur. J. Med. Chem. 44, 2765-75, (2009)

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Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. Kunal Roy et al Eur. J. Med. Chem. 44, 2913-22, (2009)

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Mono and bis-6-arylbenzimidazo[1,2-c]quinazolines: a new class of antimicrobial agents. Rondla Rohini et al Eur. J. Med. Chem. 44, 3330-9, (2009)

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Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. Naz Mohammed Aghatabay et al Eur. J. Med. Chem. 44, 365-72, (2009)

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Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents. Tarik El-Sayed Ali et al Eur. J. Med. Chem. 44, 4385-92, (2009)

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Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives. A Padmaja et al Eur. J. Med. Chem. 44, 4557-66, (2009)

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Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. Naz M Aghatabay et al Eur. J. Med. Chem. 44, 4681-9, (2009)

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Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. Andrew G S Warrilow et al Antimicrob. Agents Chemother. 53, 1157-64, (2009)

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Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. Sarah Tsao et al Antimicrob. Agents Chemother. 53, 1344-52, (2009)

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In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. Lingmei Sun et al Antimicrob. Agents Chemother. 53, 1586-91, (2009)

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Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes. Stavroula Antonopoulou et al Antimicrob. Agents Chemother. 53, 2181-4, (2009)

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Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. Patrick Vandeputte et al Antimicrob. Agents Chemother. 53, 3034-41, (2009)

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Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Monika Sharma et al Antimicrob. Agents Chemother. 53, 3256-65, (2009)

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Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Erwin Lamping et al Antimicrob. Agents Chemother. 53, 354-69, (2009)

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Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua. Shunyan Mo et al J. Nat. Prod. 72, 894-9, (2009)

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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Jing Yuan et al Nat. Chem. Biol. 5, 765-71, (2009)

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Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. James M Kraus et al J. Med. Chem. 53, 3887-98, (2010)

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Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. Qingzhong Hu et al J. Med. Chem. 53, 5049-53, (2010)

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Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. Silvia Gobbi et al J. Med. Chem. 53, 5347-51, (2010)

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Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. Qingzhong Hu et al J. Med. Chem. 53, 5749-58, (2010)

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Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs. James McNulty et al Bioorg. Med. Chem. Lett. 20, 2335-9, (2010)

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Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Yagmur Muftuoglu et al Bioorg. Med. Chem. Lett. 20, 3050-64, (2010)

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New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy. Mónica S Olivella et al Bioorg. Med. Chem. Lett. 20, 4808-11, (2010)

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Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes. Caroline P Owen et al Bioorg. Med. Chem. Lett. 20, 5345-8, (2010)

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New small-size peptides possessing antifungal activity. Francisco M Garibotto et al Bioorg. Med. Chem. 18, 158-67, (2010)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs. Kouatli Omar et al Bioorg. Med. Chem. 18, 426-32, (2010)

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Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides. Ahmed S Aboraia et al Bioorg. Med. Chem. 18, 4939-46, (2010)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines. Rondla Rohini et al Eur. J. Med. Chem. 45, 1200-5, (2010)

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An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. Bijoy P Mathew et al Eur. J. Med. Chem. 45, 1502-7, (2010)

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Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives. Ahmet Ozdemir et al Eur. J. Med. Chem. 45, 2080-4, (2010)

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Naftifine-analogues as anti-Trypanosoma cruzi agents. Alejandra Gerpe et al Eur. J. Med. Chem. 45, 2154-64, (2010)

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Synthesis and bioassay of pyrrolyl oxazolines and thiazolines. V Padmavathi et al Eur. J. Med. Chem. 45, 3178-83, (2010)

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Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. Qing-Zhong Zheng et al Eur. J. Med. Chem. 45, 3207-12, (2010)

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Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety. Yusuf Ozkay et al Eur. J. Med. Chem. 45, 3293-8, (2010)

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Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles. André P Liesen et al Eur. J. Med. Chem. 45, 3685-91, (2010)

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A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities M. D. Aytemir and B. Oezcelik, Eur. J. Med. Chem. 45, 4089-4095, (2010)

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Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles. V Padmavathi et al Eur. J. Med. Chem. 45, 4246-51, (2010)

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Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Ahmed S Aboraia et al Eur. J. Med. Chem. 45, 4427-34, (2010)

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Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. Shichong Yu et al Eur. J. Med. Chem. 45, 4435-45, (2010)

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Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid. Wen Gu et al Eur. J. Med. Chem. 45, 4692-6, (2010)

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Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives. Fernanda Mahle et al Eur. J. Med. Chem. 45, 4761-8, (2010)

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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Nidhi Puri et al Eur. J. Med. Chem. 45, 4813-26, (2010)

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Synthesis, characterization and biocidal activity of new organotin complexes of 2-(3-oxocyclohex-1-enyl)benzoic acid. Flaviana T Vieira et al Eur. J. Med. Chem. 45, 883-9, (2010)

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Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents. Wendy W J van de Sande et al Antimicrob. Agents Chemother. 54, 2738-40, (2010)

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A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Claire M Martel et al Antimicrob. Agents Chemother. 54, 3578-83, (2010)

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Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. Claire M Martel et al Antimicrob. Agents Chemother. 54, 4527-33, (2010)

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In vitro activity of thimerosal against ocular pathogenic fungi. Yan Xu et al Antimicrob. Agents Chemother. 54, 536-9, (2010)

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Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents. Emmanoel Vilaça Costa et al J. Nat. Prod. 73, 1180-3, (2010)

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The taiwaniaquinoids: a review. George Majetich et al J. Nat. Prod. 73, 284-98, (2010)

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Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum. Xiaoru Wang et al J. Nat. Prod. 73, 942-8, (2010)

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The Japanese toxicogenomics project: application of toxicogenomics. Takeki Uehara et al Mol. Nutr. Food. Res. 54, 218-27, (2010)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-?-hydroxylase/C17-20 lyase. Angela Stefanachi et al J. Med. Chem. 54, 1613-25, (2011)

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Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives Lucas, S.; et al. J. Med. Chem. 54, 2307-2319, (2011)

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New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17?-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases. Sandrine Marchais-Oberwinkler et al J. Med. Chem. 54, 534-47, (2011)

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N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). Christina Zimmer et al Bioorg. Med. Chem. Lett. 21, 186-90, (2011)

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Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation. Zhihong Xu et al Bioorg. Med. Chem. Lett. 21, 4005-7, (2011)

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Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones. Praveen, C.; et al. Bioorg. Med. Chem. Lett. 21, 4072, (2011)

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3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents. B Suresh Kuarm et al Bioorg. Med. Chem. Lett. 21, 524-7, (2011)

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Synthesis and biological evaluation of some novel triazol-3-ones as antimicrobial agents. Santosh Pardeshi et al Bioorg. Med. Chem. Lett. 21, 6559-62, (2011)

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Synthesis and antileishmanial evaluation of 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-1H-pyrazole derivatives. Maurício S dos Santos et al Bioorg. Med. Chem. Lett. 21, 7451-4, (2011)

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A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas. Y L N Murthy et al Bioorg. Med. Chem. Lett. 21, 7522-5, (2011)

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Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. Zhu-Ping Xiao et al Bioorg. Med. Chem. 19, 1571-9, (2011)

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Antifungal, cytotoxic and SAR studies of a series of N-alkyl, N-aryl and N-alkylphenyl-1,4-pyrrolediones and related compounds. M Sortino et al Bioorg. Med. Chem. 19, 2823-34, (2011)

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Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation. K Liaras et al Bioorg. Med. Chem. 19, 3135-40, (2011)

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4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. Zhu-Ping Xiao et al Bioorg. Med. Chem. 19, 3884-91, (2011)

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Novel (E)-1-(4-methyl-2-(alkylamino)thiazol-5-yl)-3-arylprop-2-en-1-ones as potent antimicrobial agents. K Liaras et al Bioorg. Med. Chem. 19, 7349-56, (2011)

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Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles. V Padmavathi et al Eur. J. Med. Chem. 46, 1367-73, (2011)

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Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 46, 1505-11, (2011)

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Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. Jianming Xu et al Eur. J. Med. Chem. 46, 3142-8, (2011)

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CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes. Aline Guerra M Fraga et al Eur. J. Med. Chem. 46, 349-55, (2011)

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Synthesis and antimicrobial evaluation of new benzofuran derivatives. Xizhen Jiang et al Eur. J. Med. Chem. 46, 3526-30, (2011)

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Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. Wei Zhang et al Eur. J. Med. Chem. 46, 3639-50, (2011)

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Penetratin analogues acting as antifungal agents. Francisco M Garibotto et al Eur. J. Med. Chem. 46, 370-7, (2011)

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Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents. Rahul V Patel et al Eur. J. Med. Chem. 46, 4354-65, (2011)

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Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones. Zhu-Ping Xiao et al Eur. J. Med. Chem. 46, 4904-14, (2011)

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Synthesis and anticandidal activity of new triazolothiadiazine derivatives. Mehlika Dilek Alt?ntop et al Eur. J. Med. Chem. 46, 5562-6, (2011)

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Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Nandita Sinha et al Eur. J. Med. Chem. 46, 618-30, (2011)

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Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major. José Ignacio Manzano et al Antimicrob. Agents Chemother. 55, 1045-52, (2011)

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FDA-approved drug labeling for the study of drug-induced liver injury. Minjun Chen et al Drug Discov. Today 16, 697-703, (2011)

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Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis. Tezuka, Y., et al. J. Nat. Prod. 74, 102-105, (2011)

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Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. Cui Li et al J. Nat. Prod. 74, 1658-62, (2011)

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Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. Peng Fu et al J. Nat. Prod. 74, 1751-6, (2011)

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Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp. Kamolchanok Tianpanich et al J. Nat. Prod. 74, 79-81, (2011)

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Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps). Zhichao Liu et al PLoS Comput. Biol. 7, e1002310, (2011)

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Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents. Vasudeva Rao Avupati et al Bioorg. Med. Chem. Lett. 22, 1031-5, (2012)

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Discovery of a novel class of aldol-derived 1,2,3-triazoles: Potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). James McNulty et al Bioorg. Med. Chem. Lett. 22, 718-22, (2012)

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Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies. P Zoumpoulakis et al Bioorg. Med. Chem. 20, 1569-83, (2012)

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Synthesis, antimicrobial, antimycobacterial and structure-activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles. Ezhumalai Yamuna et al Eur. J. Med. Chem. 47, 228-38, (2012)

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Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans. Niina Tani et al Eur. J. Med. Chem. 47, 270-7, (2012)

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Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug. Mariappan Babu et al Eur. J. Med. Chem. 47, 608-14, (2012)

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Synthesis and biological evaluation of some thiazolidinones as antimicrobial agents. Divyesh Patel et al Eur. J. Med. Chem. 48, 354-62, (2012)

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Regioselective synthesis and antimicrobial activities of some novel aryloxyacetic acid derivatives. Bakr F Abdel-Wahab et al Eur. J. Med. Chem. 50, 55-62, (2012)

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