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K1015 Sigma

K114

≥98% (HPLC), powder

Synonym: (trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene

  • CAS Number 872201-12-2

  • Empirical Formula (Hill Notation) C22H17BrO2

  • Molecular Weight 393.27

  •  MDL number MFCD11045294

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Description

Biochem/physiol Actions

K114 is a fluorescent, amyloid-specific dye, an analogue of Congo Red and BSB that recognizes amyloid lesions and allows the quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xi
Risk Statements (Europe) 
36
Safety Statements (Europe) 
26
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

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