K1015 Sigma

K114

≥98% (HPLC), powder

Synonym: (trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene

  • CAS Number 872201-12-2

  • Empirical Formula (Hill Notation) C22H17BrO2

  • Molecular Weight 393.27

  •  MDL number MFCD11045294

Properties

Related Categories Alzheimer′s Disease, Assays/Reagents for Alzheimer′s Disease Research, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: soluble >10 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

K114 is a fluorescent, amyloid-specific dye, an analogue of Congo Red and BSB that recognizes amyloid lesions and allows the quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.

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