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K1507 Sigma

Kirromycin from Streptomyces collinus

≥90% (HPLC)

Synonym: Antibiotic Myc-8003, Mocimycin

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
biological source   from Streptomyces collinus
InChI Key   HMSYAPGFKGSXAJ-DSMBXYKSSA-N
assay   ≥90% (HPLC)
color   yellow
solubility   methanol: 1.90-2.10 mg/mL clear, yellow
Mode of action   protein synthesis | interferes
  protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   −20°C

Description

Biochem/physiol Actions

Binding of kirromycin to EF-Tu prevents EF-TuGDP from being ejected from the ribosome, which immobilizes the ribsome, as well as all of the following ribosomes on the mRNA.

Packaging

5 mg in glass bottle

Application

Kirromycin is a polyketide antibiotic which is produced by the actinomycetes Streptomyces collinus. Kirromycin has been used to stimulate GTPase action of EF-Tu in the absence of programmed ribosomes in Thermus thermophilus. Kirromycin is used to study bacterial protein synthesis at the level of elongation factor EF-Tu-GDP release.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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