|Related Categories||A to C, Anti-inflammatory, Application Index, Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade,|
|Gene Information||human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)|
Non-steroidal anti-inflammatory compound that is selective for COX-1.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P301 + P310-P305 + P351 + P338|
|Personal Protective Equipment||Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T|
|Risk Statements (Europe)||25-36/37/38|
|Safety Statements (Europe)||26-45|
|RIDADR||UN 2811 6.1/PG 3|
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents. Stanislav Gobec et al Bioorg. Med. Chem. Lett. 15, 5170-5, (2005)
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Marieke Voets et al J. Med. Chem. 49, 2222-31, (2006)
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Jenny M Pedersen et al J. Med. Chem. 51, 3275-87, (2008)
Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). Emmanuel Bey et al J. Med. Chem. 51, 6725-39, (2008)
Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening. Mojca Brunskole et al Bioorg. Med. Chem. 16, 5881-9, (2008)
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)
Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties. Elisabeth Christiansen et al J. Med. Chem. 54, 6691-703, (2011)
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies. Minggui Yuan et al Bioorg. Med. Chem. 19, 1189-96, (2011)
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