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K2628 Sigma

Ketotifen fumarate salt

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Description

Biochem/physiol Actions

H1 histamine receptor antagonist.

Packaging

1 g in glass bottle

100 mg in glass bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

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≥98% (HPLC), solid

European Pharmacopoeia (EP) Reference Standard

European Pharmacopoeia (EP) Reference Standard

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
Safety Statements (Europe) 
36
WGK Germany 
3
RTECS 
DE8260000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Mast cell stabilizer, ketotifen, prevents UV-induced wrinkle formation. Kim MS, Lee DH, Lee CW, et al. J. Invest. Dermatol. 133(4), 1104-7, (2013)

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Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats. Huang P, Liu D, Gan X, et al. Injury 43(8), 1250-6, (2012)

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PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat. Fernández-Blanco JA, Hollenberg MD, Martínez V, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(4), G390-400, (2013)

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[Recent marketing authorization applications in France]. Romain O Arch. Pediatr. 19(12), 1388-91, (2012)

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Visceral hypersensitivity in IBS: from bench to bedside. van Diest SA, Stanisor OI, de Jonge WJ, et al. J. Pediatr. Gastroenterol. Nutr. 53 Suppl 2, S34-5, (2011)

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Histamine H1 receptor and reactivity of the nasal mucosa in sensitized guinea pigs. Ohkawa, et al. Auris. Nasus. Larynx. 26, 293, (1999)

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A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Eastman RT, Pattaradilokrat S, Raj DK, et al. Antimicrob. Agents Chemother. 57(1), 425-35, (2013)

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Sustained in vivo release from imprinted therapeutic contact lenses. Tieppo A, White CJ, Paine AC, et al. J. Control. Release 157(3), 391-7, (2012)

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Delivery of ketotifen fumarate by commercial contact lens materials. Soluri A, Hui A, and Jones L Optom. Vis. Sci. 89(8), 1140-9, (2012)

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Evidence for the role of mast cells in colon-bladder cross organ sensitization. Fitzgerald JJ, Ustinova E, Koronowski KB, et al. Auton. Neurosci. 173(1-2), 6-13, (2013)

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Mast cell expression of the serotonin1A receptor in guinea pig and human intestine. Wang GD, Wang XY, Zou F, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(10), G855-63, (2013)

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The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures. Monument, M.J., et al. Inflamm. Res. 61, 285-92, (2012)

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Mast cell stabilization: novel medication for obesity and diabetes. Wang J and Shi GP Diabetes. Metab. Res. Rev. 27(8), 919-24, (2011)

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The effects of the c-kit blocker glivec on the contractile response of urinary bladder. Min Y, He P, Wang Q, et al. J. Surg. Res. 171(2), e193-9, (2011)

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Characterization of antihistamines using biphasic cutaneous reaction in BALB/c mice. Inagaki, et al. Life Sci. 63, 145, (1998)

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Neurogenic airway microvascular leakage induced by toluene inhalation in rats. Sakamoto T, Kamijima M, and Miyake M Eur. J. Pharmacol. 685(1-3), 180-5, (2012)

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First and second generation H₁ histamine receptor antagonists produce different sleep-inducing profiles in rats. Unno K, Ozaki T, Mohammad S, et al. Eur. J. Pharmacol. 683(1-3), 179-85, (2012)

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Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema. Pressler A, Grosber M, Halle M, et al. Clin. Exp. Dermatol. 38(2), 151-3, (2013)

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Carryover effect on next-day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial. Katayose Y, Aritake S, Kitamura S, et al. Hum. Psychopharmacol. Clin. Exp. 27(4), 428-36, (2012)

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Δ-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity. Andrioli WJ, Santos MS, Silva VB, et al. Nat. Prod. Res. 26(23), 2168-75, (2012)

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The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. Yamada K, Takizawa F, Tamura T, et al. Biol. Pharm. Bull. 35(5), 693-7, (2012)

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Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. Milner E, Sousa J, Pybus B, et al. Eur. J. Drug Metab. Pharmacokinet. 37(1), 17-22, (2012)

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In vivo enhancement of transdermal absorption of ketotifen by supersaturation generated by amorphous form of the drug. Inoue K and Sugibayashi K Eur. J. Pharm. Sci. 47(1), 228-34, (2012)

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Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves. Kapoor M, Jasani N, Acharya N, et al. Asian Pac. J. Trop. Med. 4(8), 642-4, (2011)

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Inhibition of histamine H1 receptor activity modulates proinflammatory cytokine production of dendritic cells through c-Rel activity. Lee CL, Hsu SH, Jong YJ, et al. Int. Arch. Allergy Immunol. 160(3), 265-74, (2013)

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Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way. Zuliani JP, Freitas TA, Conceição IM, et al. Exp. Toxicol. Pathol. 65(3), 229-34, (2013)

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[Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options]. Molderings GJ, Homann J, Brettner S, et al. Dtsch. Med. Wochenschr. 139(30), 1523-34; quiz 1535-8, (2014)

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Novel delivery approach for ketotifen fumarate: dissofilms formulation using 3² experimental design: in vitro/in vivo evaluation. Fahmy RH and Badr-Eldin SM Pharm. Dev. Technol. 19(5), 521-30, (2014)

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Eosinophilic ascites resolution with ketotifen. Casella G, Villanacci V, and Bassotti G Mayo Clin. Proc. 86(10), 1027, (2011)

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Merck 14,5307

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