• USA Home
  • K2628 - Ketotifen fumarate salt

EMAIL THIS PAGE TO A FRIEND

K2628 Sigma

Ketotifen fumarate salt

Purchase

Description

Biochem/physiol Actions

H1 histamine receptor antagonist.

Packaging

1 g in glass bottle

100 mg in glass bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

TruPAGE™ Pre-cast Polyacrylamide Gels


TruPAGE™ Pre-cast Polyacrylamide GelsTruPAGE Gels run true every time!

  • . 2-Year Shelf Life
  • . Superior Band Resolution
  • . Strong & Tear Resistant
  • . Higher Capacity Wells



DISCOVER Bioactive Small Molecules

Duolink Webinar

Customers Also Viewed

Immepip dihydrobromide

≥98% (HPLC), solid

European Pharmacopoeia (EP) Reference Standard

European Pharmacopoeia (EP) Reference Standard

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
Hazard Codes (Europe) 
Xn
Risk Statements (Europe) 
22
Safety Statements (Europe) 
36
WGK Germany 
3
RTECS 
DE8260000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Histamine H1 receptor and reactivity of the nasal mucosa in sensitized guinea pigs. Ohkawa, et al. Auris. Nasus. Larynx. 26, 293, (1999)

Loading...


Characterization of antihistamines using biphasic cutaneous reaction in BALB/c mice. Inagaki, et al. Life Sci. 63, 145, (1998)

Loading...


PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat. Fernández-Blanco JA, Hollenberg MD, Martínez V, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(4), G390-400, (2013)

Loading...


Visceral hypersensitivity in IBS: from bench to bedside. van Diest SA, Stanisor OI, de Jonge WJ, et al. J. Pediatr. Gastroenterol. Nutr. 53 Suppl 2, S34-5, (2011)

Loading...


Sustained in vivo release from imprinted therapeutic contact lenses. Tieppo A, White CJ, Paine AC, et al. J. Control. Release 157(3), 391-7, (2012)

Loading...


A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Eastman RT, Pattaradilokrat S, Raj DK, et al. Antimicrob. Agents Chemother. 57(1), 425-35, (2013)

Loading...


Delivery of ketotifen fumarate by commercial contact lens materials. Soluri A, Hui A, and Jones L Optom. Vis. Sci. 89(8), 1140-9, (2012)

Loading...


Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats. Huang P, Liu D, Gan X, et al. Injury 43(8), 1250-6, (2012)

Loading...


The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures. Monument, M.J., et al. Inflamm. Res. 61, 285-92, (2012)

Loading...


Mast cell expression of the serotonin1A receptor in guinea pig and human intestine. Wang GD, Wang XY, Zou F, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(10), G855-63, (2013)

Loading...


Neurogenic airway microvascular leakage induced by toluene inhalation in rats. Sakamoto T, Kamijima M, and Miyake M Eur. J. Pharmacol. 685(1-3), 180-5, (2012)

Loading...


First and second generation H₁ histamine receptor antagonists produce different sleep-inducing profiles in rats. Unno K, Ozaki T, Mohammad S, et al. Eur. J. Pharmacol. 683(1-3), 179-85, (2012)

Loading...


The effects of the c-kit blocker glivec on the contractile response of urinary bladder. Min Y, He P, Wang Q, et al. J. Surg. Res. 171(2), e193-9, (2011)

Loading...


Mast cell stabilization: novel medication for obesity and diabetes. Wang J and Shi GP Diabetes. Metab. Res. Rev. 27(8), 919-24, (2011)

Loading...


Δ-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity. Andrioli WJ, Santos MS, Silva VB, et al. Nat. Prod. Res. 26(23), 2168-75, (2012)

Loading...


Carryover effect on next-day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial. Katayose Y, Aritake S, Kitamura S, et al. Hum. Psychopharmacol. Clin. Exp. 27(4), 428-36, (2012)

Loading...


Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema. Pressler A, Grosber M, Halle M, et al. Clin. Exp. Dermatol. 38(2), 151-3, (2013)

Loading...


Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way. Zuliani JP, Freitas TA, Conceição IM, et al. Exp. Toxicol. Pathol. 65(3), 229-34, (2013)

Loading...


Novel delivery approach for ketotifen fumarate: dissofilms formulation using 3² experimental design: in vitro/in vivo evaluation. Fahmy RH and Badr-Eldin SM Pharm. Dev. Technol. 19(5), 521-30, (2014)

Loading...


Evidence for the role of mast cells in colon-bladder cross organ sensitization. Fitzgerald JJ, Ustinova E, Koronowski KB, et al. Auton. Neurosci. 173(1-2), 6-13, (2013)

Loading...


In vivo enhancement of transdermal absorption of ketotifen by supersaturation generated by amorphous form of the drug. Inoue K and Sugibayashi K Eur. J. Pharm. Sci. 47(1), 228-34, (2012)

Loading...


Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves. Kapoor M, Jasani N, Acharya N, et al. Asian Pac. J. Trop. Med. 4(8), 642-4, (2011)

Loading...


Inhibition of histamine H1 receptor activity modulates proinflammatory cytokine production of dendritic cells through c-Rel activity. Lee CL, Hsu SH, Jong YJ, et al. Int. Arch. Allergy Immunol. 160(3), 265-74, (2013)

Loading...


The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats. Yamada K, Takizawa F, Tamura T, et al. Biol. Pharm. Bull. 35(5), 693-7, (2012)

Loading...


Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy. Milner E, Sousa J, Pybus B, et al. Eur. J. Drug Metab. Pharmacokinet. 37(1), 17-22, (2012)

Loading...


[Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options]. Molderings GJ, Homann J, Brettner S, et al. Dtsch. Med. Wochenschr. 139(30), 1523-34; quiz 1535-8, (2014)

Loading...


[Recent marketing authorization applications in France]. Romain O Arch. Pediatr. 19(12), 1388-91, (2012)

Loading...


Mast cell stabilizer, ketotifen, prevents UV-induced wrinkle formation. Kim MS, Lee DH, Lee CW, et al. J. Invest. Dermatol. 133(4), 1104-7, (2013)

Loading...


Eosinophilic ascites resolution with ketotifen. Casella G, Villanacci V, and Bassotti G Mayo Clin. Proc. 86(10), 1027, (2011)

Loading...


Merck 14,5307

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?