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K3018 Sigma

PAK3, active, GST tagged from mouse

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: Pak65alpha, Pak65beta, Stk4

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   221-298 nmol/min·mg
mol wt   mol wt ~89 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   mouse ... Pak3(18481)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

PAK3 (p21 protein (Cdc42/Rac)-activated kinase 3) is a member of the family of serine/threonine protein kinases that serve as targets for the small GTPases, Cdc42 (cell division cycle 42) and RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1). The PAK family of proteins has been implicated in a wide range of biological activities and are involved in the control of gene transcription, cell morphology, motility and cell death. A point mutation in PAK3 gene has been linked to nonsyndromic X-linked mental retardation. PAK3 is strongly expressed in brain, mainly in the hippocampus.

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