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K3768 Sigma

PYK2 (360-690), active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: CADTK, CAKB, FADK2, FAK2, PKB, PTK2B, PTK, RAFTK

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   216-292 nmol/min·mg
mol wt   mol wt ~39 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... PTK2B(2185)

Description

Physical form

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

Biochem/physiol Actions

In osteoclasts, PYK2 (proline-rich tyrosine kinase 2) might be a crucial mediator of integrin αvβ3 signaling events that affects osteoclast physiology as well as pathology. It has a tumor-promoting role in multiple myeloma.

General description

PYK2 (proline-rich tyrosine kinase 2, also known as FAK2/RAFTK) belongs to the focal adhesion PTK (protein tyrosine kinase) family. It is activated by signals that increases intracellular calcium concentration and also by stress signals. PYK2 is present in the endothelium, central nervous system, and hematopoietic lineages.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles
Peer-Reviewed Papers
15

References

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