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K3893 Sigma

PKD2, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: DKFZp586E0820, HSPC187, PRKD2

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   220-298 nmol/min·mg
mol wt   mol wt ~130 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... PRKD2(25865)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Biochem/physiol Actions

The PKD (protein kinase D) family of enzymes participates in various cellular functions, including Golgi organization and plasma membrane associated transport, metastasis, immune responses, cell death and cell proliferation. In cancers, PKD2 is associated with survival, angiogenesis as well as invasion. Absence of PKD2 can result in glioma cell senescence.

General description

PKD2 (protein kinase D2) is a phorbol ester- and growth factor-activated serine/threonine kinase that has two cysteine-rich motifs, a pleckstrin homology domain and a catalytic domain. It is widely expressed and belongs to the protein kinase D family.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water

Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
Protocols & Articles
Peer-Reviewed Papers
15

References

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