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  • K4764 - Anti-Potassium Channel sloβ2 (KCNMB2) antibody produced in rabbit

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K4764 Sigma

Anti-Potassium Channel sloβ2 (KCNMB2) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym: Anti-BKCa β subunit 2

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Properties

Related Categories Alphabetical Index, Antibodies, POD-POZ, Primary Antibodies
species reactivity   rat, mouse, canine
application(s)   immunohistochemistry: suitable using rat brain sections
  western blot: 1:200 using rat kidney and heart samples
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Kcnmb2(294961)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

peptide (C)RHDEKRNIYQKIRDHDLLD, corresponding to amino acid residues 14-32 of human sloβ2.

Antigen Background

The sloβ2 subunit is unique because it is able to induce a rapid and complete inactivation of the KCa1.1 channel in a manner that closely resembles the ball-and-chain inactivation of the voltage-dependent K+ (Kv) channels.The inactivation is dependent on a sequence in the N-terminal part of the sloβ2 subunit that appears to block the mouth of the ion permeation pathway. sloβ2 subunit appears to participate in the inactivation of the KCa1.1 channel in hippocampal CA1 neurons and adrenal chromaffin cells.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

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