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Key intermediate in the breakdown pathway of tryptophan.
L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. L-kynurenine is involved in a variety of neurological processes and diseases. L-kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.
Inhibition of Indoleamine 2,3-Dioxygenase Activity by Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia trachomatis Persistence in Human Epithelial Cells. Ibana JA, Belland RJ, Zea AH, et al. Infect. Immun. 79, 4425-4437, (2011)
Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. Santiago Lima et al J. Med. Chem. 52, 389-96, (2009)
Involvement of kynurenines in Huntington's disease and stroke-induced brain damage. Stone TW, Forrest CM, et al. J. Neural Transm. Gen. Sect. 119(2), 261-74, (2011)
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