Anti-LRRK2 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
DOWNLOAD MSDS (PDF)Synonym: Anti-AURA17, Anti-Dardarin, Anti-Leucine-rich repeat protein kinase 2, Anti-PARK8, Anti-RIPK7, Anti-ROCO2
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Properties
| Related Categories | Alphabetical Index, Antibodies, Antibodies for Parkinson’s Disease Research, Antibodies in Array, Cell Biology, |
| species reactivity | human |
| application(s) | western blot: 1-2 μg/mL using HEK-293T cells expressing human LRRK2 |
| clone | polyclonal |
| concentration | ~1.0 mg/mL |
| antibody form | affinity isolated antibody |
| form | buffered aqueous solution |
| mol wt | antigen mol wt ~240 kDa |
| shipped in | dry ice |
| storage temp. | −20°C |
| Gene Information |
human ... LRRK2(120892) mouse ... Lrrk2(66725) rat ... (300160) |
Description
Immunogen
synthetic peptide corresponding to amino acids 2512-2527 of human LRRK2 conjugated to KLH. The corresponding sequence is highly conserved (~80% identity) in mouse and rat LRRK2.
General description
LRRK2 is a μLtimeric kinase that also functions as a GTPase. LRRK2 activates a CaMKK-β/AMPK signaling pathway and subsequently mediates autophagy. Genetic alterations in LRRK2 cause late-onset Parkinson′s disease 1,2. Anti-LRRK2 (C-terminal) antibody is specific for human LRRK2 (approx. 240 kDa). Staining of the LRRK2 band by immunoblotting is specifically inhibited by the LRRK2 immunizing peptide.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Application
Anti-LRRK2 (C-terminal) antibody is suitable for use in western blot (1-2 μg/mL using HEK-293T cells expressing human LRRK2).
Price and Availability
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