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L0258 Sigma

L-701,324

≥98% (HPLC), solid

Synonym: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenylquinolin-2[1H]-one

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids,
InChI Key   FLVRDMUHUXVRET-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: 36.4 mg/mL
Gene Information   human ... GRIN1(2902)
rat ... Grin1(24408), Grin2a(24409)

Description

Packaging

10, 50 mg in glass bottle

Legal Information

Manufactured and sold under license from Merck, Sharp and Dohme, Ltd. U.S. Patent No. 5,348,962.

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Biochem/physiol Actions

L-701,324 is a high affinity, selective antagonist at the glycine site of the NMDA glutamate receptor. L-701,324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
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3
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers
15

References

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