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L1026 Sigma

Lidocaine

analytical standard

Synonym: 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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Lidocaine hydrochloride

pharmaceutical secondary standard; traceable to PhEur and BP

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Safety Information

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GHS07  GHS07
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Warning
Hazard statements 
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WGK Germany 
3
RTECS 
AN7525000

Protocols & Articles

Peer-Reviewed Papers

References

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Hepatitis C Virus NS2 Is A Protease Stimulated By Cofactor Domains In NS3. Schregel, V., et al. Proc. Natl. Acad. Sci. U. S. A. 106, 5342-7, (2009)

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Mitochondrial Heat Shock Protein (HSP) 70 Synergizes With HSP60 In Transducing Endothelial Cell Apoptosis Induced By Anti-HSP60 Autoantibody. Alard, J.E., et al. FASEB J. 23, 2772-9, (2009)

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Gustav Ahlin et al J. Med. Chem. 51, 5932-42, (2008)

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. Giorgio Ottaviani et al J. Med. Chem. 49, 3948-54, (2006)

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Intravenous lidocaine for the treatment of background or procedural burn pain. Wasiak J, Mahar P, McGuinness SK, et al. Cochrane Database Syst. Rev. 6, CD005622, (2012)

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Molecular characteristics for solid-state limited solubility. Carola M Wassvik et al J. Med. Chem. 51, 3035-9, (2008)

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Resuscitation Outcomes Consortium-Amiodarone, Lidocaine or Placebo Study (ROC-ALPS): Rationale and methodology behind an out-of-hospital cardiac arrest antiarrhythmic drug trial. Kudenchuk PJ, Brown SP, Daya M, et al. Am. Heart J. 167(5), 653-9.e4, (2014)

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Fecal continence revisited: the anal external sphincter continence reflex. Broens PM, Penninckx FM, and Ochoa JB Dis. Colon Rectum 56(11), 1273-81, (2013)

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High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. Yveline Henchoz et al J. Med. Chem. 51, 396-9, (2008)

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Lipophilicity of basic drugs measured by hydrophilic interaction chromatography. Bruno Bard et al J. Med. Chem. 52, 3416-9, (2009)

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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bram Baert et al Bioorg. Med. Chem. 15, 6943-55, (2007)

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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. Giorgio Ottaviani et al J. Med. Chem. 50, 742-8, (2007)

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. R Scott Obach et al Drug Metab. Dispos. 36, 1385-405, (2008)

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Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation. Bertrand Plouvier et al J. Med. Chem. 50, 2818-41, (2007)

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Physicochemical determinants of human renal clearance. Manthena V S Varma et al J. Med. Chem. 52, 4844-52, (2009)

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Spatial navigation. Disruption of the head direction cell network impairs the parahippocampal grid cell signal. Winter SS, Clark BJ, and Taube JS Science 347(6224), 870-4, (2015)

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Management of aphonic patients following total laryngectomy and trachea esophageal puncture. Benyamini L, Gil Z, and Cohen JT Isr. Med. Assoc. J. 16(12), 768-70, (2014)

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Ultrasound-guided axillary tunnel block: the 'comet tail' block. Cornish PB Anaesth. Intensive Care 43(1), 130-1, (2015)

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Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents. Parekh S, Gardener C, Ashley PF, et al. Cochrane Database Syst. Rev. 12, CD009742, (2014)

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Effects of lidocaine on random skin flap survival in rats. Cao B, Wang L, Lin D, et al. Dermatol. Surg. 41(1), 53-8, (2015)

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Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation. Chen J, Winston JH, Fu Y, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(1), R18-27, (2015)

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Neurally mediated propagating discrete clustered contractions superimposed on myogenic ripples in ex vivo segments of human ileum. Kuizenga MH, Sia TC, Dodds KN, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 308(1), G1-G11, (2015)

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[Topical pharmacologic approach with 5% lidocaine medicated plaster in the treatment of localized neuropathic pain]. Provinciali L, Lattanzi S, Chiarlone R, et al. Minerva Med. 105(6), 515-27, (2014)

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Lidocaine contact allergy is becoming more prevalent. To D, Kossintseva I, and de Gannes G Dermatol. Surg. 40(12), 1367-72, (2014)

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iTMJ reduction. Hebard RL Otolaryngol. Head Neck Surg. 151(6), 1086-7, (2014)

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The efficacy of lidocaine to prevent laryngospasm in children: a systematic review and meta-analysis. Mihara T, Uchimoto K, Morita S, et al. Anaesthesia 69(12), 1388-96, (2014)

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Anesthetic efficacy of a combination of 0.5 M mannitol plus 36.8 mg of lidocaine with 18.4 μg epinephrine in maxillary infiltration: a prospective, randomized, single-blind study. Younkin K, Reader A, Drum M, et al. Anesth. Prog. 61(2), 63-8, (2014)

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Lidocaine concentration in mandibular bone after subperiosteal infiltration anesthesia decreases with elevation of periosteal flap and irrigation with saline. Ogawa S, Watanabe M, Kawaai H, et al. Anesth. Prog. 61(2), 53-62, (2014)

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When can a normal dose be an overdose? Who is at risk? Weaver JM Anesth. Prog. 61(2), 45-6, (2014)

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Improving the local anesthesia experience for our patients. Kurtzman GM Dent. Today 33(4), 120, 122, 124 passim, (2014)

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[Efficacy and safety of remifentanil-based regimen for postoperative pain management in abdominal surgery patients: a double-blind study with low-dose remifentanil infusion of 0.02 microg x kg(-1) x min(-1)]. Nagasaka Y, Wakamatsu M, Hirano H, et al. Masui. 63(4), 475-9, (2014)

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A Bier block implementation protocol. Stancil SA US Army Med. Dep. J., 53-6, (2014)

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Comparison of articaine and lidocaine in the pediatric population. Smith T, Urquiola R, Oueis H, et al. J. Mich. Dent. Assoc. 96(1), 34-7, (2014)

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[Anesthesiological support of surgical intervention on clavicular osteosynthesis in patients with multiple rib fractures]. Kuchyn IuL Klin. Khir. (12), 58-60, (2013)

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[Effect of cervical paravertebral block combined with acupuncture intervention on cervicogenic headache]. Wu JX, Fan RJ, Song WX, et al. Zhen Ci Yan Jiu 38(5), 411-4, (2013)

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Inhibition of murine cardiomyocyte respiration by amine local anesthetics. Aburawi EH and Souid AK Eur. J. Drug Metab. Pharmacokinet. 39(4), 293-9, (2014)

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WITHDRAWN: Topical lidocaine for the treatment of postherpetic neuralgia. Khaliq W, Alam S, and Puri NK Cochrane Database Syst. Rev. 10, CD004846, (2013)

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[Necrosis in fingers and toes following local anaesthesia with adrenaline--an urban legend?]. Finsen V Tidsskr. Nor. Laegeforen. 133(17), 1827-30, (2013)

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Anaphylactic reaction to intraurethral chlorhexidine: sensitisation following previous repeated uneventful administration. Dyer JE, Nafie S, Mellon JK, et al. Ann. R. Coll. Surg. Engl. 95(6), e105-6, (2013)

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Epinephrine in local anesthesia in finger and hand surgery: the case for wide-awake anesthesia. Lalonde D and Martin A J. Am. Acad. Orthop. Surg. 21(8), 443-7, (2013)

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[Efficient treatment of breakthrough pain in adults: the importance of timing and medication choice]. Berna C, Luthy C, Samer CF, et al. Rev. Med. Suisse 9(392), 1360, 1362-5, (2013)

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Topical lidocaine to suppress trigemino-cardiac reflex. Meuwly C, Chowdhury T, and Schaller B Br. J. Anaesth. 111(2), 302, (2013)

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Comparison of three methods of preventing rocuronium induced pain on injection using venous occlusion technique: a randomized prospective double blind controlled study. Abu-Halaweh SA, Aloweidi AK, Qudaisat IY, et al. Middle East J. Anesthesiol. 22(1), 87-92, (2013)

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Spinal anaesthesia for pelvic surgery: low concentrations of lignocaine and bupivacaine are effective with less adverse events. Punj J and Khan RM Middle East J. Anesthesiol. 22(1), 71-7, (2013)

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The effectivity of periprostatic nerve blockade for the pain control during transrectal ultrasound guided prostate biopsy. Otunctemur A, Dursun M, Besiroglu H, et al. Arch. Ital. Urol. Androl. 85(2), 69-72, (2013)

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[Investigation of the influence of intracameral injection of domestic lidocaine on the corneal thickness during phacoemulsification of cataract]. Tutchenko LP, Znamens'ka MA, Dzhulaĭ MV, et al. Lik. Sprava (8), 92-6, (2012)

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Effectiveness and safety of lidocaine in the induction of fetal cardiac asystole for second trimester pregnany termination. López-Cepero R, Lynch L, and de la Vega A Bol. Asoc. Med. P. R. 105(1), 14-7, (2013)

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[Fatal exposure to Aconitum napellus]. German Jørgensen JR and Andersen AE Ugeskr. Laeg. 175(24), 1707-8, (2013)

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The effect of sonophoresis on topical anesthesia: a pilot project. Packer JL, Krall B, Makki A, et al. Anesth. Prog. 60(2), 37-41, (2013)

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Catheter lubrication and fixation: interventions. Wilson M Br. J. Nurs. 22(10), 566, 568-9, (2013)

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Management options in neuropathic pain. Paliwal VK and Pradhan S J. Indian Med. Assoc. 110(9), 639-43, (2012)

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Use of ophthalmic lidocaine gel as an anesthetic for intravitreal injections. Koffron P, Jacobsen J, and Gehrs K Insight 38(2), 22-3, (2013)

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[Epidural pharmacotherapy in the treatment of the pain syndrome in osteochondrosis complicated by intervertebral discs protrusion of lumbar part of the vertebral column]. Khizhniak MV and Priĭmak EV Klin. Khir. (3), 44-6, (2013)

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[Comparative study on effect of acupuncture and lidocaine block for lumbar myofascial pain syndrome]. Jiang GM, Lin MD, and Wang LY Zhongguo Zhen Jiu 33(3), 223-6, (2013)

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Faster onset and more comfortable injection with alkalinized 2% lidocaine with epinephrine 1:100,000. Malamed SF, Tavana S, and Falkel M Compend. Contin. Educ. Dent. 34 Spec No 1, 10-20, (2013)

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[Anaphylactic shock following administration of lidocaine after negative skin test]. Khokhlov VD, Krut' MI, and Sashko SIu Klin. Med. (Mosk.) 90(7), 62-4, (2012)

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[Capsaicin and lidocaine usage in functional disorders of urinary bladder]. Juszczak K and Thor PJ Folia Med. Cracov. 51(1-4), 91-8, (2011)

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A synthetical view of pediatrics, lidocaine, and procedural pain relief. Spillman N Plast. Surg. Nurs. 32(2), 54-8; quiz 59-60, (2012)

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[Intravesical therapy of heparin and lidocaine for interstitial cystitis : a case report]. Matsuo T, Shida Y, Hayashida Y, et al. Hinyokika Kiyo. 57(9), 513-6, (2011)

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Amiodarone supplants lidocaine in ACLS and CPR protocols. Mizzi A, Tran T, Mangar D, et al. Anesthesiol. Clin. 29(3), 535-45, (2011)

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[Study of local anaesthetics--Part 194. Evaluation of carbopol hydrogels with lidocaine]. Vitková Z, Herdová P, Cizmárik J, et al. Ceska. Slov. Farm. 60(2), 79-83, (2011)

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Spectrophotometric determination of drugs with iodine. Karuna T, et al. J. Sci. Ind. Res. 65(10), 808, (2006)

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A randomized trial of epidural glucocorticoid injections for spinal stenosis. Friedly JL, Comstock BA, Turner JA, et al. N. Engl. J. Med. 371(1), 11-21, (2014)

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Small-molecule aggregates inhibit amyloid polymerization. Brian Y Feng et al Nat. Chem. Biol. 4, 197-9, (2008)

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Denis Fourches et al Chem. Res. Toxicol. 23, 171-83, (2010)

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Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Johannes Kornhuber et al J. Med. Chem. 51, 219-37, (2008)

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Developing structure-activity relationships for the prediction of hepatotoxicity. Nigel Greene et al Chem. Res. Toxicol. 23, 1215-22, (2010)

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In utero diagnosis of long QT syndrome by magnetocardiography. Cuneo BF, Strasburger JF, Yu S, et al. Circulation 128(20), 2183-91, (2013)

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Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Francisco J Prado-Prado et al Bioorg. Med. Chem. 18, 2225-31, (2010)

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Local anesthetics in liposuction: considerations for new practice advisory guidelines to improve patient safety. Pace MM, Chatterjee A, Merrill DG, et al. Plast. Reconstr. Surg. 131(5), 820e-6e, (2013)

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Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Hong Wan et al J. Med. Chem. 52, 1693-700, (2009)

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Time-dependent modulation of muscarinic m1/m3 receptor signalling by local anaesthetics. Picardi S, Stevens MF, Hahnenkamp K, et al. Br. J. Anaesth. 112(2), 370-9, (2014)

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Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Peters CM, Ririe D, Houle TT, et al. Anesthesiology 120(4), 976-86, (2014)

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Published evidence demonstrating the causation of glenohumeral chondrolysis by postoperative infusion of local anesthetic via a pain pump. Matsen FA and Papadonikolakis A J. Bone Joint Surg. Am. 95(12), 1126-34, (2013)

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Sidedness of carbamazepine accessibility to voltage-gated sodium channels. Jo S and Bean BP Mol. Pharmacol. 85(2), 381-7, (2014)

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5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury. Eftychia N Koini et al J. Med. Chem. 52, 2328-40, (2009)

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Compensatory changes in cellular excitability, not synaptic scaling, contribute to homeostatic recovery of embryonic network activity. Wilhelm JC Proc. Natl. Acad. Sci. U. S. A. 106(16), 6760-5, (2009)

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Adjusting the pH of lidocaine for reducing pain on injection. Cepeda MS, Tzortzopoulou A, Thackrey M, et al. Cochrane Database Syst. Rev. (12), CD006581, (2010)

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Topical pain management with the 5% lidocaine medicated plaster--a review. Mick G and Correa-Illanes G Curr. Med. Res. Opin. 28(6), 937-51, (2012)

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Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Larry J Jolivette et al J. Pharm. Pharm. Sci. 94, 1467-83, (2005)

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Small-volume 7.5% NaCl adenosine, lidocaine, and Mg2+ has multiple benefits during hypotensive and blood resuscitation in the pig following severe blood loss: rat to pig translation. Granfeldt A, Letson HL, Hyldebrandt JA, et al. Crit. Care Med. 42(5), e329-44, (2014)

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A predictive ligand-based Bayesian model for human drug-induced liver injury. Sean Ekins et al Drug Metab. Dispos. 38, 2302-8, (2010)

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Lidocaine reduces neutrophil recruitment by abolishing chemokine-induced arrest and transendothelial migration in septic patients. Berger C, Rossaint J, Van Aken H, et al. J. Immunol. 192(1), 367-76, (2014)

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Transcutaneous aortic valve replacement with the Edwards SAPIEN XT and Medtronic CoreValve prosthesis under fluoroscopic guidance and local anaesthesia only. Greif M, Lange P, Näbauer M, et al. Heart 100(9), 691-5, (2014)

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Antiarrhythmic, serotonin antagonist and antianxiety activities of novel substituted thiophene derivatives synthesized from 2-amino-4,5,6,7-tetrahydro-N-phenylbenzo[b]thiophene-3-carboxamide. Abd El-Galil E Amr et al Eur. J. Med. Chem. 45, 5935-42, (2010)

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Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Michael H Abraham et al Eur. J. Med. Chem. 43, 478-85, (2008)

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Novel quinolizidinyl derivatives as antiarrhythmic agents. Iana Vazzana et al J. Med. Chem. 50, 334-43, (2007)

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Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial. Mari FS, Nigri G, Dall'Oglio A, et al. Dis. Colon Rectum 56(6), 768-73, (2013)

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In vivo synaptic scaling is mediated by GluA2-lacking AMPA receptors in the embryonic spinal cord. Garcia-Bereguiain MA, Gonzalez-Islas C, Lindsly C, et al. J. Neurosci. 33(16), 6791-9, (2013)

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Comparison of tolerance and cost-effectiveness of two nasal anesthesia techniques for transnasal flexible laryngoscopy. Young VN, Smith LJ, and Rosen CA Otolaryngol. Head Neck Surg. 150(4), 582-6, (2014)

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Clinical practice. Postherpetic neuralgia. Johnson RW and Rice AS N. Engl. J. Med. 371(16), 1526-33, (2014)

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Coronary responses to cold air inhalation following afferent and efferent blockade. Muller MD, Gao Z, McQuillan PM, et al. Am. J. Physiol. Heart Circ. Physiol. 307(2), H228-35, (2014)

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Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Nandita Sinha et al Eur. J. Med. Chem. 46, 618-30, (2011)

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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Lei Du-Cuny et al Bioorg. Med. Chem. 17, 6983-92, (2009)

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Evidence for therapeutic uses of nebulized lidocaine in the treatment of intractable cough and asthma. Slaton RM, Thomas RH, and Mbathi JW Ann. Pharmacother. 47(4), 578-85, (2013)

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Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation. Bruno Tasso et al J. Med. Chem. 53, 4668-77, (2010)

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Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Yun W Alelyunas et al Bioorg. Med. Chem. Lett. 20, 7312-6, (2010)

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Evaluation of the local anaesthetic activity of 3-aminobenzo[d]isothiazole derivatives using the rat sciatic nerve model. Athina Geronikaki et al Eur. J. Med. Chem. 44, 473-81, (2009)

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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Naomi L Kruhlak et al Toxicol. Mech. Methods 18, 217-27, (2008)

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Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human. K W Ward et al Xenobiotica 35, 191-210, (2005)

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QSAR-based solubility model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 18, 7078-84, (2010)

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First-principle, structure-based prediction of hepatic metabolic clearance values in human. Haiyan Li et al Eur. J. Med. Chem. 44, 1600-6, (2009)

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Lidocaine-prilocaine (EMLA(®) ) cream as analgesia in hysteroscopy practice: a prospective, randomized, non-blinded, controlled study. Arnau B, Jovell E, Redón S, et al. Acta Obstet. Gynecol. Scand. 92(8), 978-81, (2013)

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Efficacy and safety of mepivacaine compared with lidocaine in local anaesthesia in dentistry: a meta-analysis of randomised controlled trials. Su N, Liu Y, Yang X, et al. Int. Dent. J. 64(2), 96-107, (2014)

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QSAR-based permeability model for drug-like compounds. Rafael Gozalbes et al Bioorg. Med. Chem. 19, 2615-24, (2011)

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Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results. Alster T, Garden J, Fitzpatrick R, et al. J. Dermatolog. Treat. 25(2), 174-7, (2014)

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Surgeon-administered conscious sedation and local anesthesia for ambulatory anorectal surgery. Hina M, Hourigan JS, Moore RA, et al. Am. Surg. 80(1), 21-5, (2014)

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Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. Xiaofan Sui et al Eur. J. Med. Chem. 44, 4455-60, (2009)

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Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation. Alessio Coi et al Eur. J. Med. Chem. 43, 2479-88, (2008)

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Pain fiber anesthetic reduces brainstem Fos after tooth extraction. Badral B, Davies AJ, Kim YH, et al. J. Dent. Res. 92(11), 1005-10, (2013)

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Safety and efficacy of a novel nasal spray for maxillary dental anesthesia. Ciancio SG, Hutcheson MC, Ayoub F, et al. J. Dent. Res. 92(7 Suppl), 43S-8S, (2013)

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Intraperitoneal local anesthetics have predominant local analgesic effect: a randomized, double-blind study. Perniola A, Magnuson A, Axelsson K, et al. Anesthesiology 121(2), 352-61, (2014)

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Emulsified isoflurane enhances thermal transient receptor potential vanilloid-1 channel activation-mediated sensory/nociceptive blockade by QX-314. Zhou C, Liang P, Liu J, et al. Anesthesiology 121(2), 280-9, (2014)

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A non-inferiority randomized controlled trial comparing the clinical effectiveness of anesthesia obtained by application of a novel topical anesthetic putty with the infiltration of lidocaine for the treatment of lacerations in the emergency department. Jenkins MG, Murphy DJ, Little C, et al. Ann. Emerg. Med. 63(6), 704-10, (2014)

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Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine. Nayak A and Das DB Biotechnol. Lett. 35(9), 1351-63, (2013)

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Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophore. Yuesheng Wang et al Bioorg. Med. Chem. 17, 7064-72, (2009)

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Intranasal topical local anesthetic and decongestant for flexible nasendoscopy in children: a randomized, double-blind, placebo-controlled trial. Chadha NK, Lam GO, Ludemann JP, et al. JAMA Otolaryngol. Head Neck Surg. 139(12), 1301-5, (2013)

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Effect of intra-articular local anesthesia on articular cartilage in the knee. Ravnihar K, Barlič A, and Drobnič M Arthroscopy 30(5), 607-12, (2014)

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Methemoglobinemia induced by lidocaine-prilocaine cream. Shamriz O, Cohen-Glickman I, Reif S, et al. Isr. Med. Assoc. J. 16(4), 250-4, (2014)

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Hemodynamic rescue and ECG stability during chest compressions using adenosine and lidocaine after 8-minute asphyxial hypoxia in the rat. Djabir Y and Dobson GP Am. J. Emerg. Med. 31(11), 1539-45, (2013)

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Herpes zoster: diagnostic, therapeutic, and preventive approaches. Bader MS Postgrad. Med. 125(5), 78-91, (2013)

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Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action. Jorge C S Costa et al Bioorg. Med. Chem. Lett. 18, 1162-6, (2008)

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Mechanisms of lidocaine's action on subtypes of spinal dorsal horn neurons subject to the diverse roles of Na(+) and K(+) channels in action potential generation. Wolff M, Schnöbel-Ehehalt R, Mühling J, et al. Anesth. Analg. 119(2), 463-70, (2014)

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A comparison of lidocaine and bupivacaine digital nerve blocks on noninvasive continuous hemoglobin monitoring in a randomized trial in volunteers. Miller RD, Ward TA, McCulloch CE, et al. Anesth. Analg. 118(4), 766-71, (2014)

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Transcutaneous electrical nerve stimulation in combination with cobalamin injection for postherpetic neuralgia: a single-center randomized controlled trial. Xu G, Xú G, Feng Y, et al. Am. J. Phys. Med. Rehabil. 93(4), 287-98, (2014)

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Spectrum of myelinated pulmonary afferents (II). Liu J and Yu J Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(9), R1059-64, (2013)

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A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. Huaping Mo et al Bioorg. Med. Chem. Lett. 20, 6712-5, (2010)

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Implementing a fast-track protocol for patients undergoing bowel resection: not so fast. Hui V, Hyman N, Viscomi C, et al. Am. J. Surg. 206(2), 152-8, (2013)

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Comparison of anaesthetic and analgesic effects of emulsified isoflurane used alone or combined with lidocaine and fentanyl in dogs. Fan HG, Jiang S, Lin DQ, et al. N. Z. Vet. J. 62(3), 123-9, (2014)

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Evaluation of the efficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate. Jindal T, Mandal SN, Biswas G, et al. Ann. R. Coll. Surg. Engl. 95(5), 361-4, (2013)

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Pre-emptive penile ring block with sucrose analgesia reduces pain response to neonatal circumcision. Roman-Rodriguez CF, Toussaint T, Sherlock DJ, et al. Urology 83(4), 893-8, (2014)

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[Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage]. Herminghaus A, Wachowiak M, Wilhelm W, et al. Anaesthesist 60(2), 152-60, (2011)

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Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Pil H Lee et al Bioorg. Med. Chem. Lett. 20, 69-73, (2010)

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Trends in pharmacy compounding for women's health in North Carolina: focus on vulvodynia. Corbett SH, Cuddeback G, Lewis J, et al. South. Med. J. 107(7), 433-6, (2014)

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Lidocaine toxicity secondary to local anesthesia administered in the community for elective circumcision. Menif K, Khaldi A, Bouziri A, et al. Fetal Pediatr. Pathol. 30(6), 359-62, (2011)

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Pain management with a topical lidocaine and tetracaine 7%/7% cream with laser dermatologic procedures. Cohen JL Journal. of. Drugs in. Dermatology. 12(9), 986-9, (2013)

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Effect of alkalinisation of lignocaine for propofol injection pain: a prospective, randomised, double-blind study. Ozgul U, Begec Z, Erdogan MA, et al. Anaesth. Intensive Care 41(4), 501-4, (2013)

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Episodic syncope caused by ventricular flutter in a tiger (Panthera tigris). DeLillo DM, Jesty SA, and Souza MJ J. Zoo Wildl. Med. 44(2), 500-4, (2013)

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Supraorbital and infraorbital nerve blockade in migraine patients: results of 6-month clinical follow-up. Ilhan Alp S and Alp R Eur. Rev. Med. Pharmacol. Sci. 17(13), 1778-81, (2013)

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The importance of anatomical region of local anesthesia for prostate biopsy; a randomized clinical trial. Akdere H, Burgazli KM, Aktoz T, et al. Eur. Rev. Med. Pharmacol. Sci. 17(21), 2890-5, (2013)

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An alternative local anaesthesia technique to reduce pain in paediatric patients during needle insertion. Lee SH and Lee NY Eur. J. Paediatr. Dent. 14(2), 109-12, (2013)

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[Intraosseous blocks in the treatment of symmetrical distal diabetic polyneuropathy]. Sokov EL, Kornilova LE, and Artiukov OP Ter. Arkh. 85(4), 61-5, (2013)

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Histological evaluation of a jet injection of 2 per cent lidocaine solution on the oral mucosa of a mixed-breed dog. A review and experimental study. Bell WA, Traeger KA, and Hansen LS Oral Surg. Oral Med. Oral Pathol. 31(1), 79-86, (1971)

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Epidural glucocorticoid injections in patients with lumbar spinal stenosis. Andersson GB N. Engl. J. Med. 371(1), 75-6, (2014)

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Intrauterine instillation of lignocaine gel does not help in reducing pain after endometrial ablation. Hazarika T, Laxton A, Savant R, et al. Anaesth. Intensive Care 42(4), 524-5, (2014)

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In reply. Hopper SM, Babl FE, and Babl FE Ann. Emerg. Med. 64(1), 97, (2014)

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Viscous lidocaine treatment for painful oral infections in children: disappointingly dismissive of pediatric pain. Hoffman RJ Ann. Emerg. Med. 64(1), 96-7, (2014)

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The "submarine hatch" nail bed biopsy. Zaiac MN, Norton ES, and Tosti A J. Am. Acad. Dermatol. 70(6), e127-8, (2014)

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Nebulised local anaesthesia technique for fish bone removal. Svecova N and Ward M Ann. R. Coll. Surg. Engl. 96(4), 321, (2014)

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Is perioperative intravenous lidocaine for complex spine surgery a more complex issue? Fry RA and Davis K Anesthesiology 120(5), 1298, (2014)

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Reply: analgesic efficacy of lidocaine for suction-assisted lipectomy with tumescent technique under general anesthesia: a randomized, double-masked, controlled trial. Danilla S Plast. Reconstr. Surg. 133(4), 598e-9e, (2014)

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Analgesic efficacy of Lidocaine for suction-assisted lipectomy with tumescent technique under general anesthesia: a randomized, double-masked, controlled trial. Miranda EP Plast. Reconstr. Surg. 133(4), 597e-8e, (2014)

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Hydraulic expulsion of tumbu fly larvae. Dybbro E, Fordyce P, Ponte M, et al. JAMA Dermatol. 150(7), 791-2, (2014)

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The evolution of transcutaneous aortic valve replacement: moving in the right direction. Shavelle DM Heart 100(9), 683-4, (2014)

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Comparison of postoperative redness of eyes after sub-Tenon's block and topical anaesthesia following phacoemulsification cataract surgery. Huang P, Gopal L, and Kumar CM Br. J. Anaesth. 112(2), 381-2, (2014)

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Reply by the authors. Ghosh B and Dorairajan LN Urology 82(6), 1454, (2013)

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"One-per-mil" tumescent technique for hand surgery. Prasetyono TO and Biben JA Plast. Reconstr. Surg. 132(6), 1091e-2e, (2013)

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Food for thought: atrioventricular dissociation. Singh GD, Wong GB, Southard JA, et al. Am. J. Med. 126(12), 1050-3, (2013)

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A reply. Sinha R and Saxena R Anaesthesia 68(9), 985-6, (2013)

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Duration of lidocaine gel for squint surgery. Mandal N Anaesthesia 68(9), 984-5, (2013)

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Editor-in-Chief's reply. Yentis SM Anaesthesia 68(9), 980, (2013)

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Laryngeal reflex responses in anaesthetised children: breach of international research governance. Schumacher J and Stratling MW Anaesthesia 68(9), 979-80, (2013)

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Best BETs from the Manchester Royal Infirmary. BET 2: should intranasal lidocaine be used in patients with acute cluster headache? Morgan A and Jessop V Emerg. Med. J. 30(9), 769-70, (2013)

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New method of percutaneous radiofrequency mandibular nerve rhizotomy guided by high-speed real-time computed tomography fluoroscopy with direct approaching view to foramen ovale. Nakajima K, Koizuka S, and Saito S Br. J. Anaesth. 111(2), 299-300, (2013)

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In response. Grady MV, Mascha E, Sessler DI, et al. Anesth. Analg. 116(4), 950-1, (2013)

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Editor-in-chief's reply. Yentis SM Anaesthesia 68(5), 536, (2013)

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A reply. Erb TO, Keller K, Frei FJ, et al. Anaesthesia 68(5), 535-6, (2013)

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Laryngeal reflex responses in anaesthetised children: anaesthesia was right to publish. Girard T Anaesthesia 68(5), 534-5, (2013)

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Laryngeal reflex responses in anaesthetised children: ethics and methodology. Cowley NJ Anaesthesia 68(5), 533-4, (2013)

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Articaine is superior to lidocaine in providing pulpal anesthesia. Powell V J. Am. Dent. Assoc. 143(8), 897-8, (2012)

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