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L1044 Sigma

Anti-Leukemia Inhibitory Factor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-LIF

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Description

Immunogen

purified, E. coli-derived recombinant mouse leukemia inhibitory factor.

General description

Leukemia inhibitory factor (LIF) is a pleotropic glycoprotein that belongs to the IL6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. LIF interacts with a heterodimeric receptor composed of two subunits, gp130 and gp190. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-cFos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic ell differentiation. Reports also indicate the important role of LIF in lactation, tissue regeneration after brain and spinal cord injury, muscle regeneration and motor neuron functions.
Anti-Leukemia Inhibitory Factor recognizes mouse leukemia inhibitory factor. It shows less than 5% cross-reactivity with recombinant human LIF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Application

Anti-Leukemia Inhibitory Factor may be used in neutralization reactions at a working concentration of 0.5 ng/ml. For immunoblotting a concentration of 0.1-0.2 μg/ml is recommended.

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Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
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WGK Germany  1
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Peer-Reviewed Papers
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References

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