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L1294 Sigma

Lactoferrin human

recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)

Synonym: Holo Transferrin

Properties

recombinant   expressed in rice
type   for cell culture
assay   ≥90% (SDS-PAGE)
  ≥90% (biuret)
impurities   ≤10 EU/mg endotoxin
solubility   0.1 M NaCl: soluble10 mg/mL
  0.1 M sodium phosphate buffer pH 6.7: soluble10 mg/mL
storage temp.   2-8°C

Description

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium.1 It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.2

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