L1294 Sigma

Lactoferrin human

recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)

Synonym: Holo Transferrin



recombinant   expressed in rice
type   for cell culture
assay   ≥90% (SDS-PAGE)
  ≥90% (biuret)
impurities   ≤10 EU/mg endotoxin
solubility   0.1 M NaCl: soluble10 mg/mL
  0.1 M sodium phosphate buffer pH 6.7: soluble10 mg/mL
storage temp.   2-8°C


Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.


1 g in poly bottle

100 mg in poly bottle


Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium.1 It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.2

Price and Availability

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Lactoferrin from human milk

≥85% (SDS-PAGE), lyophilized powder

Iron saturated, ≥85% (SDS-PAGE)

powder, BioReagent, suitable for cell culture

iron-saturated, ≥85% (GE)

Safety & Documentation

Safety Information

WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers


Set your institution to view full text papers.

1. Growth of Streptococcus mutans in an iron-limiting medium. Grace A. Spatafora, Meagan W. Moore Methods Cell Sci. 1-4th ed., 20, 217-221, (1998)

2. Lactoferrin impedes epithelial cell adhesion in vitro. Pöllänen MT, Häkkinen L, Overman DO, et al. J. Periodont. Res. 33(1), 8-16, (1998)


The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis. Rousseau E, Michel PP, and Hirsch EC Mol. Pharmacol. 84(6), 888-98, (2013)


Human lactoferrin stimulates skin keratinocyte function and wound re-epithelialization. Tang L, Wu JJ, Ma Q, et al. Br. J. Dermatol. 163(1), 38-47, (2010)


A rice-derived recombinant human lactoferrin stimulates fibroblast proliferation, migration, and sustains cell survival. Tang L, Cui T, Wu JJ, et al. Wound Repair Regen. 18(1), 123-31, (2010)


Bioactive recombinant human lactoferrin, derived from rice, stimulates mammalian cell growth. Huang N, Bethell D, Card C, et al. In Vitro Cell. Dev. Biol. Anim. 44(10), 464-71, (2008)


Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives. Antonelli AC, Zhang Y, Golub LM, et al. J. Enzyme Inhib. Med. Chem. 29(5), 663-9, (2014)


Comparison of bioactivities of talactoferrin and lactoferrins from human and bovine milk. Jiang R, Du X, Lönnerdal B, et al. J. Pediatr. Gastroenterol. Nutr. 59(5), 642-52, (2014)


Corneal cell adhesion to contact lens hydrogel materials enhanced via tear film protein deposition. Elkins CM, Qi QM, and Fuller GG PLoS ONE 9(8), e105512, (2014)


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