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L1418 Sigma

Anti-LAMP1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Lysosomal-associated membrane protein 1, Anti-CD107a, Anti-LAMPA, Anti-LGP120

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cell and Organelle Proteins, Antibodies to Cytoplasm,
species reactivity   human, mouse, rat
application(s)   indirect immunofluorescence: 5-10 μg/mL using human HeLa, rat NRK, and mouse NIH3T3 cells
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~120 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acid residues 405-416 of human LAMP1 with N-terminal added cysteine-glycine, conjugated to KLH. The corresponding sequence is identical in rat and mouse.

General description

The gene LAMP1 (lysosomal-associated membrane protein 1) encodes a type I transmembrane protein that has a short cytoplasmic tail containing a lysosome-targeting signal of GYQTI(382)-COOH. The gene is mapped to human chromosome 13q34.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-LAMP1-Cy3® antibody produced in rabbit has been used in western blotting and immunofluorescence.

Legal Information

CAB-O-SIL is a registered trademark of Cabot Corp.

Biochem/physiol Actions

The gene LAMP1 (lysosomal associated membrane protein 1) encodes a membrane glycoprotein that functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. Lamp1 is crucial for perforin trafficking to the lytic granules and motility of these lytic granules. Its knockdown leads to inhibition of cytotoxicity of human natural killer cells.

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