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  • L1795 - Anti-PLAGL1 (C-terminal) antibody produced in rabbit

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L1795 Sigma

Anti-PLAGL1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-LOT-1, Anti-Lost on transformation 1, Anti-PLAL1, Anti-Pleiomorphic adenoma-like protein 1, Anti-Tumor supressor ZAC

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Gene Regulation and Expression, Antibodies to Transcription Factors,
species reactivity   human
application(s)   indirect immunofluorescence: 0.5-1 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human PLAGL1
  western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human PLAGL1
clone   polyclonal
concentration   ~1.0 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~50 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PLAGL1(5325)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 332-348 of human PLAGL1 conjugated to KLH.

General description

The gene PLAGL1 (pleiomorphic adenoma-like protein 1), PLAGL2 and PLAG1 form a subfamily of PLAG family of zinc finger proteins that recognize DNA and RNA. The three members share similarity at the amino-terminal, but are functionally different, varying in their DNA binding capacities. The gene is mapped to human chromosome 6q24.2, a region implicated in several cancers.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Biochem/physiol Actions

The maternally-imprinted gene, PLAGL1 (pleiomorphic adenoma-like protein 1), functions as an oncogene as well as a tumor suppressor depending on the cell context. It has been found to exhibit anti-proliferative properties and regulate apoptosis and cell-cycle arrest via p53.

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