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L1898 Sigma

[D-Ala6]-LH-RH acetate salt hydrate

≥97% (HPLC)

Synonym: (D-Ala-6) Luteinizing Hormone Releasing Hormone

  • Empirical Formula (Hill Notation) C56H77N17O13 · xC2H4O2 · yH2O

  • Molecular Weight 1196.32 (anhydrous free base basis)

  •  PubChem Substance ID 24896296

  • Popular Documents:  Specification Sheet (PDF)  

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins,
InChI Key   KGUIXKYKIZMKMT-JGUOWLKQSA-N
assay   ≥97% (HPLC)
composition   Peptide content, ≥65%
storage temp.   −20°C
Gene Information   human ... GNRH1(2796)

Description

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Ala-Leu-Arg-Pro-Gly-NH2

Biochem/physiol Actions

Potent LH-RH agonist.

(D-Ala6)-LH-RH is a GnRH (gonadotropin-releasing hormone) agonist. GnRH, which is also referred to as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.

Packaging

5 mg in glass bottle

Application

[D-Ala6]-LH-RH acetate salt hydrate has been used to induce ovulation and to synchronize the reproductive cycle in Sprague-Dawley female rats.

Price and Availability


Amplified Detection

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
OK6400000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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