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L2139 Sigma

Lipoprotein, low density from human plasma

buffered aqueous solution, from human plasma

Synonym: β-Lipoprotein, LDL, Low density lipoprotein

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Properties

biological source   from human plasma
sterility   0.22 μm filtered
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C

Description

Caution

Freezing may cause denaturation.

Packaging

Package size based on protein content

Physical form

Solution in 0.15 M NaCl with 0.01% EDTA, pH 7.4

Biochem/physiol Actions

LDL and HDL transport both dietary and endogenous cholesterol in the plasma. LDL is the main transporter of cholesterol and cholesteryl esters and makes up more than half of the total lipoprotein in plasma. LDL is absorbed by the liver and other tissues via receptor mediated endocytosis. The cytoplasmic domain of the LDL receptor facilitates the formation of coated pits; receptor-rich regions of the membrane. The ligand binding domain of the receptor recognizes apo-B100 on LDL, resulting in the formation of a clathrin-coated vesicle. ATP-dependent proton pumps lower the pH inside the vesicle resulting dissociation of LDL from its receptor. After loss of the clathrin coat the vesicles fuse with lysozomes, resulting in peptide and cholesteryl ester enzymatic hydrolysis. The LDL receptor can be recycled to the cell membrane. Insulin, tri-iodothyronine and dexamethasome have shown to be involved with the regulation of LDL receptor mediated uptake.

Physical properties

Low density lipoproteins are smaller than VLDL and IDL (26 nm) (MW approximately 3.5 million) and more dense (~1.04). The protein component of LDL is apolipoprotein B100. LDL contains 20-22% protein, 10-15% triglycerides, 20-28% phospholipids, 37-48% cholesteryl esters and 8-10% cholesterol.

Price and Availability

Safety & Documentation

Safety Information

WGK Germany 
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Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Omega-3 Fatty Acids and Heart Disease

The potential for the prevention and treatment of cardiovascular disease through increased dietary intake of omega-3 (w-3) fish oils is not a recent scientific discovery. A historically important stu...
BioFiles 2007, 2.2, 14.
Keywords: Anti-inflammatory agents, Biochemistry, Cardiovascular, Clinical, Degradations, Esterifications, Immunology, Inflammation, Lipid Metabolism, Metabolism, Metabolites, Methods, Nutrition, Oxidations, Transcription

Peer-Reviewed Papers
15

References

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L7914 Lipoprotein, low density from human plasma, ≥95% (SDS-PAGE), solution

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