|Related Categories||Bacteria-derived adjuvants, Bioactive Small Molecules, Cell Biology, Cell Culture, Cell Signaling and Neuroscience,|
|purified by||gel-filtration chromatography|
|impurities||<5% Protein (Lowry)|
|solubility||H2O: soluble5 mg/mL, slightly hazy|
|suitability||suitable for cell culture|
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Lipopolysaccharides are supplied as lyophilized, γ-irradiated powders. To reconstitute, add 1 ml sterile balanced salt solution or tissue culture medium to the vial (1 mg) and gently swirl until the powder dissolves. Reconstituted product may be further diluted to desired working concentrations using sterile balanced salt solution or tissue culture medium.
LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from mice, rabbits, chickens, cows, hamsters, and humans.
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Host Soluble Factors That Regulate The Synthesis Of The Major Core Protein Of The Bovine Leukemia Virus (BLV) In A Naturally Infected Neoplastic B-cell Line. Gutiérrez, S., et al. Vet. Immunol. Immunopathol. 131, 246-58, (2009)
Diversity of interferon γ and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis. Stefanie B Flohé et al Mol. Med. 14, 247-56, (2008)
Mechanisms of leukocyte distribution during sepsis: an experimental study on the interdependence of cell activation, shear stress and endothelial injury. Annette Ploppa et al Critical Care 14, R201, (2010)
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|L4391||Lipopolysaccharides from Escherichia coli 0111:B4, γ-irradiated, BioXtra, suitable for cell culture|
|L6529||Lipopolysaccharides from Escherichia coli 055:B5, γ-irradiated, BioXtra, suitable for cell culture|
|L4516||Lipopolysaccharides from Escherichia coli 0127:B8, BioXtra, suitable for cell culture, γ-irradiated|
|L4641||Lipopolysaccharides from Salmonella enterica serotype minnesota, γ-irradiated, BioXtra, suitable for cell culture|
|L6143||Lipopolysaccharides from Salmonella enterica serotype typhimurium, BioXtra, suitable for cell culture, γ-irradiated|
|L7895||Lipopolysaccharides from Salmonella typhosa, γ-irradiated, BioXtra, suitable for cell culture|
|L7770||Lipopolysaccharides from Salmonella enterica serotype enteritidis, γ-irradiated, BioXtra, suitable for cell culture|
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