Lipopolysaccharides from Escherichia coli 026:B6
γ-irradiated, BioXtra, suitable for cell culture
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MDL number MFCD00164401
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Popular Documents: Datasheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Bacteria-derived adjuvants, Bioactive Small Molecules, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, |
| Quality Level | PREMIUM |
| sterility | γ-irradiated |
| product line | BioXtra |
| form | lyophilized powder |
| purified by | gel-filtration chromatography |
| impurities | <5% Protein (Lowry) |
| solubility | H2O: soluble5 mg/mL, slightly hazy |
Description
Application
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Reconstitution
Lipopolysaccharides are supplied as lyophilized, γ-irradiated powders. To reconstitute, add 1 ml sterile balanced salt solution or tissue culture medium to the vial (1 mg) and gently swirl until the powder dissolves. Reconstituted product may be further diluted to desired working concentrations using sterile balanced salt solution or tissue culture medium.
Biochem/physiol Actions
LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from mice, rabbits, chickens, cows, hamsters, and humans.
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