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L2774 Sigma

Lincomycin hydrochloride

BioReagent, suitable for cell culture

Synonym: Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

  • CAS Number 859-18-7

  • Empirical Formula (Hill Notation) C18H34N2O6S · HCl

  • Molecular Weight 443.00

  •  Beilstein Registry Number 4171650

  •  EC Number 212-726-7

  •  MDL number MFCD00083647

  •  PubChem Substance ID 329817401

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Properties

Related Categories Antibacterial, Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
InChI Key   POUMFISTNHIPTI-BOMBIWCESA-N
product line   BioReagent
potency   800-900 units per mg
color   white
solubility   H2O: soluble4 mL, clear, colorless to faintly yellow (200 mg + 4 mL H2O)
suitability   suitable for cell culture
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Application

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It is produced by Streptomyces lincolnensis var. lincolnensis, and has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

Biochem/physiol Actions

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

Packaging

1000000, 5000000 units in glass bottle

Preparation Note

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
RH6315000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Inhibition of Protein Synthesis by Antibiotics

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere wi...
BioFiles 2006, 1.4, 17.
Keywords: Antibiotics, Environmental, Peptide synthesis

Peer-Reviewed Papers
15

References

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