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L2885 Sigma

Lymphotoxin-β Receptor/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: TNF R-related protein, TNF RIII

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, TNF Receptors,
recombinant   expressed in NSO cells
assay   >95% (SDS-PAGE)
form   lyophilized powder
mol wt   monomer calculated mol wt 49.6 kDa
  mol wt 70 kDa by SDS-PAGE (reducing) (due to glycosylation)
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... LTBR(4055)

Description

Analysis Note

The biological activity is measured by the ability of the immobilized LTβR/Fc to bind LTα2/β1 and LTα1/β2 in a functional ELISA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Biochem/physiol Actions

LTBR (lymphotoxin β receptor) is a receptor for LIGHT (tumor necrosis factor ligand superfamily member 14) and LT (lymphotoxin)-a1β2. It is present in the epithelial, stromal and myeloid cells. LTBR participates in lymphoid organ development and immune homeostasis. It is also involved in the lipopolysaccharide (LPS)-mediated expression of IL (interleukin)-8.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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