• USA Home
  • L2913 - Leptomycin B solution from Streptomyces sp.

EMAIL THIS PAGE TO A FRIEND
L2913 Sigma

Leptomycin B solution from Streptomyces sp.

≥95% (HPLC), Supplied in methanol: water (7:3)

Purchase

Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antifungal, Bioactive Small Molecule Alphabetical Index,
Quality Level   PREMIUM
InChI Key   YACHGFWEQXFSBS-XYERBDPFSA-N
assay   ≥95% (HPLC)
storage condition   protect from light
shipped in   dry ice
storage temp.   −20°C

Description

Biochem/physiol Actions

Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. Leptomycin B is a specific inhibitor of proteins containing nuclear export signal. Leptomycin B inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region.

General description

Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, I?B, MPF, PKA and MEK.

Other Notes

The volume in each sku is 0.1 mL with 10-20% overpack.

Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
Flash Point(F) 
64.4 °F
Flash Point(C) 
18 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?