LRRK2 monoclonal antibody | Western, ELISA, Immunocytochemistry | L3044

Properties

Related Categories	Alphabetical Index, Antibodies, Antibodies for Parkinson’s Disease Research, Antibodies in Array, Cell Biology, Cell Signaling and Neuroscience, Clone Index, LRR-LZ, Neurobiology, Neuroscience, P, Panorama Antibody Array- Neurobiology, Parkinson′s Disease, Primary Antibodies, Products for Neurodegenerative Disease Research, Protein Arrays More...
species reactivity	human, mouse
application(s)	immunocytochemistry: suitable
	indirect ELISA: suitable
	western blot: 1-2 μg/mL using mouse brain crude extract
clone	PROK57, monoclonal
concentration	~1.0 mg/mL
antibody form	purified immunoglobulin
form	buffered aqueous solution
isotype	IgM
mol wt	antigen mol wt ~250 kDa
shipped in	dry ice
storage temp.	−20°C
Gene Information	human ... LRRK2(120892) mouse ... Lrrk2(66725)

Description

Immunogen

synthetic peptide corresponding to amino acids 2499-2514 of human LRRK2.

General description

LRRK2 is a μLtimeric kinase that also functions as a GTPase. LRRK2 activates a CaMKK-β/AMPK signaling pathway and subsequently mediates autophagy. Genetic alterations in LRRK2 cause late-onset Parkinson′s disease ^1,². Monoclonal Anti-LRRK2 antibody is specific for human and mouse LRRK2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Monoclonal Anti-LRRK2 antibody is suitable for use in western blot (1-2 μg/mL using mouse brain crude extract), immunoblot (approx. 250 kDa), indirect ELISA and immunocytochemistry.

Price and Availability

Anti-Mouse 2° Antibody Best Sellers

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Documents

Certificate of Analysis

Antibody Explorer

Compatible Secondary Abs

L3044 - Datasheet (84 KB)

Safety Information

Personal Protective Equipment

Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)

Technical information & documentation associated with this product is available in the Safety & Documentation tab.

Articles

Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 6 million people worldwide. PD is a slowly progressing motor system neurod...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 16–20
Keywords: Alzheimer Disease, Apoptosis, Chromatin immunoprecipitation, Clinical, Degradations, Dopamine agents, Gene expression, Parkinson Disease, Polymorphisms

References

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1. Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Gomez-Suaga, P., et al. Hum. Mol. Genet. 21(3), 511-25, (2012)

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2. LRRK2 in Parkinson's disease: biochemical functions. Anand, V., S., and Braithwaite, S., P. FEBS J. 276(22), 6428-35, (2009)

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