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L3044 Sigma

Monoclonal Anti-LRRK2 antibody produced in mouse

~1.0 mg/mL, clone PROK57, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-AURA17, Anti-Dardarin, Anti-Leucine-rich repeat protein kinase 2, Anti-PARK8, Anti-RIPK7, Anti-ROCO2

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Parkinson’s Disease Research, Cell Biology, Cell Signaling and Neuroscience,
species reactivity   human, mouse
application(s)   immunocytochemistry: suitable
  indirect ELISA: suitable
  western blot: 1-2 μg/mL using mouse brain crude extract
clone   PROK57, monoclonal
concentration   ~1.0 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgM
mol wt   antigen mol wt ~250 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... LRRK2(120892)
mouse ... Lrrk2(66725)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 2499-2514 of human LRRK2.

General description

LRRK2 is a μLtimeric kinase that also functions as a GTPase. LRRK2 activates a CaMKK-β/AMPK signaling pathway and subsequently mediates autophagy. Genetic alterations in LRRK2 cause late-onset Parkinson′s disease . Monoclonal Anti-LRRK2 antibody is specific for human and mouse LRRK2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Monoclonal Anti-LRRK2 antibody is suitable for use in western blot (1-2 μg/mL using mouse brain crude extract), immunoblot (approx. 250 kDa), indirect ELISA and immunocytochemistry.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
Protocols & Articles

Articles

Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 6 million people worldwide. PD is a slowly progressing motor system neurod...
Carolyn L. Crankshaw
BioFiles v7 n2, 2011, 16–20
Keywords: Alzheimer Disease, Apoptosis, Chromatin immunoprecipitation, Clinical, Degradations, Dopamine agents, Gene expression, Parkinson Disease, Polymorphisms

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Peer-Reviewed Papers
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References

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