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  • L3288 - [D-His(Bzl)6]-LH-RH Fragment 5-9 Ethylamide trifluoroacetate salt

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L3288 Sigma

[D-His(Bzl)6]-LH-RH Fragment 5-9 Ethylamide trifluoroacetate salt

>98% (HPLC)

  • Empirical Formula (Hill Notation) C41H59N11O6

  • Molecular Weight 801.98

  •  MDL number MFCD03452946

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins,
assay   >98% (HPLC)
storage temp.   −20°C
Gene Information   human ... GNRH1(2796), GNRHR(2798)
mouse ... GNRH1(14714), GNRHR(14715)
rat ... GNRH1(25194), GNRHR(81668)

Description

Amino Acid Sequence

Tyr-His(Bz)-Leu-Arg-Pro-NHEt

Biochem/physiol Actions

Tyr-His(Bz)-Leu-Arg-Pro-NHEt ([D-His(Bzl)6]-LH-RH Fragment 5-9) is a peptide from GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children.

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Amplified Detection

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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