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L3772 Sigma

Leptin from mouse

>98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: OB

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Gastrointestinal Peptides,
recombinant   expressed in E. coli
assay   >98% (SDS-PAGE)
form   lyophilized powder
mol wt   predicted mol wt ~16 kDa
storage temp.   −20°C
Gene Information   mouse ... Lep(16846)

Description

Analysis Note

Bioassay determined by an in vivo assay using the ob/ob mouse obesity model and NZO

Physical form

Lyophilized from 0.1% TFA

Application

Leptin from mouse has been used:
• to check the effect of leptin on ovulation for treating infertility in obese mice
• to check the effect of leptin on MGARP (mitochondria-localized glutamic acid-rich protein) expression in testis and follicular granular cells of mice
• to study the morphometrical changes in mouse testicular tissue upon long term exposure to leptin

Biochem/physiol Actions

Absence of leptin in mice causes severe obesity and hypothermia at temperature below thermoneutrality. It also controls feeding behavior. Leptin signaling is crucial for the bone formation.

Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.

Price and Availability


Amplified Detection

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Lipid Induced Insulin Resistance

Obesity is a well-established risk factor for the development of insulin resistance. Obesity is associated with the increased deposition of lipids in non-adipose tissue with subsequent decreases in i...
Linda Stephenson, Ph.D.
Biofiles v6 n4, 9
Keywords: Angiogenesis, Antivirals, Apoptosis, Biological processes, Cardiovascular, Catalog, Catalysis, Cell culture, Cell proliferation, Deposition, Diabetes, Events, Gene expression, Growth factors, Hormones, Inflammation, Metabolism, Metabolites, Obesity, Phosphorylations, Physiological Processes, Reductions, Transcription, Transduction, Type

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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