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L4129 Sigma

L-α-Lysophosphatidylcholine from egg yolk

≥99%, Type I, powder

Synonym: 1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin

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Properties

Related Categories Biochemicals and Reagents, Cell Culture, Core Bioreagents, Detergents, Detergents A to M,
description   zwitterionic
type   Type I
assay   ≥99%
form   powder
color   white
storage temp.   −20°C

Description

Packaging

1 g in poly bottle

25, 100, 500 mg in poly bottle

Preparation Note

Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.

Quality

Contains primarily palmitic and stearic acids.

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

Price and Availability


The Future of Bioimaging
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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Product #

Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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