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L4513 Sigma

[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate

≥97% (HPLC), powder

  • Empirical Formula (Hill Notation) C56H78N16O12 · xC2H4O2 · yH2O

  • Molecular Weight 1167.32 (anhydrous free base basis)

  •  MDL number MFCD11046043

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins,
InChI Key   YEEHIOYEWOESQR-PFHUABGLSA-N
assay   ≥97% (HPLC)
form   powder
storage temp.   −20°C
Gene Information   mouse ... GNRH1(2796), GNRHR(2798)
rat ... GNRH1(14714), GNRHR(14715)

Description

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Ala-Leu-Arg-Pro-NHEt

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

Potent LH-RH agonist in rats and mice; reversibly delays sexual maturation in rats, stimulates spawning activity in fish. GnRH ( gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism.

Price and Availability


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Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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