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L4538 Sigma

[D-His(Bzl)6]-LH-RH Fragment 1-7

>96% (HPLC)

  • Empirical Formula (Hill Notation) C53H62N12O11

  • Molecular Weight 1043.13

  •  MDL number MFCD03452955

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins,
assay   >96% (HPLC)
storage temp.   −20°C

Description

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu

Biochem/physiol Actions

Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu ([D-His(Bzl)6]-LH-RH Fragment 1-7) is a peptide from GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children.

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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