|Related Categories||Apoptosis and Cell Cycle, Attachment Factors, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,|
|surface coverage||1‑2 μg/cm2|
|Gene Information||human ... LAMB1(3912)|
Laminin supports growth and differentiation of many cell types including epithelial, endothelial, neural, muscle, and liver cells.
Laminin is an epithelial cell adhesion glycoprotein, which is composed of 3 chains designated α1, β1, and γ1. Laminin promotes adhesion, differentiation, migration, and growth of many cells in vitro. Laminin is produced in human fibroblasts and epithelial cells in a co-culture system, which produces an extracellular matrix composed of many proteins, including laminin. Laminin is then purified biochemically and provided as a sterile solution at a concentration of 0.5 mg/ml in TBS (tris buffered saline), pH7.4.
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Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. Verpelli C, Dvoretskova E, Vicidomini C, et al. J. Biol. Chem. 286(40), 34839-50, (2011)
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