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L4787 Sigma

Leptin Receptor/Fc Chimera human

≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: B219

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Gastrointestinal Peptides,
recombinant   expressed in NSO cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... LEPR(3953)

Description

Biochem/physiol Actions

Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.

Leptin receptor (LEPR) is linked with risk of coronary artery disease. Mutation in LEPR is associated with low BMI (body mass index), increased leptin levels and some cancers. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.

Physical form

Lyophilized from 20 mM Tris containing 5 mg of bovine serum albumin.

General description

The gene LEPR (leptin receptor) is mapped to human chromosome 1p31. The neuroendocrine hormone, leptin, works through leptin receptor.

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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