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L4788 Sigma

[D-Trp6]-LH-RH-Leu-Arg-Pro-Gly-NH2

≥96% (HPLC)

Synonym: Triptorelin-Leu-Arg-Pro-Gly Amide

  • Empirical Formula (Hill Notation) C83H115N25O17

  • Molecular Weight 1734.96

  •  MDL number MFCD03093474

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, LH-RH, Neuropeptides, Peptides and Proteins,
InChI Key   PVYPXXICFOKNOB-NMBRWIPZSA-N
assay   ≥96% (HPLC)
storage temp.   −20°C
Gene Information   human ... CHRNA1(2796)

Description

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH2

Biochem/physiol Actions

Glp-His-Trp-Ser-Tyr-Trp-Leu-Arg-Pro-Gly-Leu-Arg-Pro-Gly-NH2 ([D-Trp6]-LH-RH-Leu-Arg-Pro-Gly-NH2) is a GnRH (gonadotropin-releasing hormone) agonist, triptorelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Triptorelin is used for the treatment of hormone-associated prostate and breast cancers, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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