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L4912 Sigma

Leptin Receptor/Fc Chimera from mouse

≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Synonym: B219

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Gastrointestinal Peptides,
recombinant   expressed in NSO cells
assay   ≥97% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   mouse ... Lepr(16847)

Description

Biochem/physiol Actions

Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.

Leptin receptor is important for regulating appetite and energy expenditure. The neuroendocrine hormone, leptin, works through leptin receptor. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.

Physical form

Lyophilized from 20 mM Tris containing 5 mg of bovine serum albumin per 100 μg leptin receptor.

Price and Availability


Amplified Detection

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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