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L5004 Sigma

L-α-Lysophosphatidylcholine from bovine liver

~99%, Type III, powder

Synonym: 1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin

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Properties

Related Categories Biochemicals and Reagents, Glycerophosphocholines, Glycerophospholipids, Lipids
type   Type III
assay   ~99%
form   powder
color   white
storage temp.   −20°C

Description

Preparation Note

Prepared by the action of phospholipase A on bovine liver L-α-phosphatidylcholine.

Quality

Contains primarily palmitic and stearic acids.

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
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L4129 L-α-Lysophosphatidylcholine from egg yolk, ≥99%, Type I, powder

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