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L5162 Sigma

Lymphotoxin-α1/β2 human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonym: LT-α, LT-β, TNF-β, Tumor Necrosis Factor-β

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Properties

Related Categories Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytokines & Growth Factors, Cytokines and Growth Factors,
recombinant   expressed in baculovirus infected Sf21 cells
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... LTA(4049), LTB(4050)

Description

Analysis Note

The biological activity is measured in a cytotoxicity assay using the TNF-susceptible mouse L929 cell line in the presence of actinomycin D.

Biochem/physiol Actions

Lymphotoxin-α (LT-α), also known as tumor necrosis factor-β (TNF-β), and lymphotoxin-β (LT-β) are members of the TNF family. Secreted LT-α complexes with the membrane-associated LT-β to generate two types of heterotrimers, LTα1/β2 and LTα2/β1. The predominant membrane-bound heterotrimer LTα1/β2 binds and activates only to the lymphotoxin β receptor (LT-βR). The other heterotrimer LTα2/β1 binds and activates TNF RI, TNF RII, and LT-βR. LT is critical for normal lymphoid organ development. LT is expressed by activated naive CD4 cells, unpolarized IL-2-secreting effectors, and Th1 effector cells.

Mutations in LTA (lymphotoxin-α) are associated with myasthenia gravis.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
Peer-Reviewed Papers
15

References

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