Synonym: 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
|Related Categories||Bile acids and Derivatives, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, L,|
human ... POLA1(5422), TOP2A(7153)|
rat ... Polb(29240)
Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. 1 It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. 2
Lithocholic acid is an oligo(ethylene glycol) derivative of bile acid. 3
10, 25 g in poly bottle
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. L6250.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine. Bile acids...
BioFiles 2007, 2.7, 17.
Keywords: Absorption, Digestions, Transcription
Deciphering the role of charge, hydration, and hydrophobicity for cytotoxic activities and membrane interactions of bile acid based facial amphiphiles. Singh M, Singh A, Kundu S, et al. Biochim. Biophys. Acta 1828(8), 1926-37, (2013)
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Yoneno K, Hisamatsu T, Shimamura K, et al. Immunology 139(1), 19-29, (2013)
Consumption of vitamin B(6) reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet. Okazaki Y, Utama Z, Suidasari S, et al. J. Nutr. Sci. Vitaminol. 58(5), 366-70, (2012)
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. He HB, Gao LX, Deng QF, et al. Bioorg. Med. Chem. Lett. 22(23), 7237-42, (2012)
Calcium- and voltage-gated potassium (BK) channel activators in the 5β-cholanic acid-3α-ol analogue series with modifications in the lateral chain. Bukiya AN, Patil SA, Li W, et al. ChemMedChem 7(10), 1784-92, (2012)
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Burstein MT, Kyryakov P, Beach A, et al. Cell Cycle 11(18), 3443-62, (2012)
Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor? Duboc H, Aelion H, Rainteau D, et al. Hepatology 56(6), 2426, (2012)
Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury. Wang YG, Zhou JM, Ma ZC, et al. Chem. Biol. Interact. 200(1), 11-20, (2012)
Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid. Jehle J, Staudacher I, Wiedmann F, et al. Br. J. Pharmacol. 167(7), 1563-72, (2012)
Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent. Bukiya AN, McMillan JE, Fedinec AL, et al. Mol. Pharmacol. 83(5), 1030-44, (2013)
Corp MSDS 1 (1), 2160:B / FT-IR 2 (3), 4239:B / FT-IR 1 (2), 1056:C / FT-NMR 1 (3), 592:B / IR-Spectra (3), 1499:C / RegBook 1 (2), 2867:G / Sax 6, 1713 / Sigma FT-IR 1 (1), 1278:C / Structure Index 1, 459:C:4
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