L6250 Sigma

Lithocholic acid


Synonym: 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol


Related Categories Bile acids and Derivatives, Biochemicals and Reagents, Lipids, Sterol Lipids
assay   ≥95%
mp   183-188 °C(lit.)
Gene Information   human ... POLA1(5422), TOP2A(7153)
rat ... Polb(29240)



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Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. 1 It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ. 2

Biochem/physiol Actions

Bile Acid

General description

Lithocholic acid is an oligo(ethylene glycol) derivative of bile acid. 3


10, 25 g in poly bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. L6250.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

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Fatty Acid and Sterol Extraction Kits

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Cholic acid

from ox or sheep bile, ≥98%

Lithocholic acid

European Pharmacopoeia (EP) Reference Standard

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