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L6250 Sigma

Lithocholic acid

≥95%

Synonym: 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol

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Properties

Related Categories Bile acids and Derivatives, Biochemicals and Reagents, Lipids, Sterol Lipids
assay   ≥95%
mp   183-188 °C(lit.)
Gene Information   human ... POLA1(5422), TOP2A(7153)
rat ... Polb(29240)

Description

Application

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Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ.

Biochem/physiol Actions

Bile Acid

General description

Lithocholic acid is an oligo(ethylene glycol) derivative of bile acid.

Packaging

10, 25 g in poly bottle

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. L6250.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability


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Polymeric Drug Delivery Techniques Guide
Safety & Documentation

Safety Information

WGK Germany 
2
RTECS 
FZ2275000
Protocols & Articles

Articles

Bile Acids

The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine. Bile acids...
BioFiles 2007, 2.7, 17.
Keywords: Absorption, Digestions, Transcription

Fast and Robust HPLC Separation of Bile Acids and Conjugates with Ascentis Express C18

Introduction Bile acids are increasingly recognized as playing an important signaling role in the control of immune response and energy metabolism. Recently, there has been interest in measuring bile...
Clare Glicksman, Michael Wright, Dave Bell, and Anders Fridström
Reporter US, Volume 33.1
Keywords: Bacterial conjugations, Biochemistry, Chromatography, Clinical, Clinical Chemistry, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Sample preparations, Separation, Solvents, Thin layer chromatography

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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