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  • L6895 - Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant)

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L6895 Sigma

Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant)

lyophilized powder, TLR ligand tested

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Properties

Related Categories Bacteria-derived adjuvants, Biochemicals and Reagents, Cell Culture, Complex Lipids, Core Bioreagents,
Quality Level   PREMIUM
form   lyophilized powder
impurities   <0.2% Ketodeoxyoctonate (KDO)
storage temp.   2-8°C

Description

Biochem/physiol Actions

Lipid A has immunostimulatory adjuvant activity including macrophage, T-cell, and B-cell activation. Research has shown Lipid A has greater Th1 than Th2 stimulation.

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Packaging

1, 5 mg in glass bottle

Application

Lipid A molecules compose the lipid membrane anchoring core components of endotoxins produced by Gram-negative bacteria. Lipid A molecules induce immune responses. Structually, lipid A molecules are composed of two glucosamine units with varied, species dependent, fatty acyl chain numbers and identity and degree of phosphorylation.
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 may be used in comparative assessment of the antigenicity of specific structures within different LPA molecules and analogues.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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