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L6910 Sigma

In Vivo Liposome Transfection Reagent

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Properties

storage temp.   2-8°C

Description

Biochem/physiol Actions

When DNA is mixed with the DOTAP:cholesterol (1:1 molar ratio) extruded liposomes, it becomes condensed in the liposome interior. The liposomes are stable at high concentration and with a high concentration of DNA, allowing large quantities of DNA to be delivered in vivo. Transfection efficiency is correspondingly high. Transfection of cells in animals provides a tool to study gene expression in vivo, to alter gene expression, and to express foreign genes in the living host.

Other Notes

Liposomes extruded from 20 mM DOTAP, 20 mM cholesterol in 5% glucose.

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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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