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L7007 Sigma

Lysergic acid diethylamide

Synonym: LSD, Lysergide

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Description

Biochem/physiol Actions

Potent hallucinogen; non-selective serotonin receptor agonist.

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Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
T+
Risk Statements (Europe) 
Safety Statements (Europe) 
22-28-36-45
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
KE4100000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD). Backstrom, J.R. Neuropsychopharmacology 21, 77, (1999)

Transcriptomic And Metabolic Responses Of Staphylococcus Aureus Exposed To Supra-physiological Temperatures. Fleury, B., et al. BMC Microbiol. 9, 76, (2009)

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Biofilm Formation By Group A Streptococcus: A Role For The Streptococcal Regulator Of Virulence (Srv) And Streptococcal Cysteine Protease (SpeB). Doern, C.D., et al. Microbiology 155, 46-52, (2009)

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Generation And Characterization Of Col10a1-mcherry Reporter Mice. Maye, P., et al. Genes Cells 49, 410-8, (2011)

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Structural basis for molecular recognition at serotonin receptors. Wang C, Jiang Y, Ma J, et al. Science 340(6132), 610-4, (2013)

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Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. Gasser P, Holstein D, Michel Y, et al. J. Nerv. Ment. Dis. 202(7), 513-20, (2014)

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Genetic toxicology of lysergic acid diethylamide (LSD-25). Cohen MM and Shiloh Y Mutat. Res. 47(3-4), 183-209, (1977)

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[Serotonin and D-lysergic acid diethylamide receptors in the mammalian brain]. Vlasova TI and Kirzon MV Nauchnye Doki. Vyss. Shkoly. Biol. Nauki (5), 5-16, (1981)

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The us of LSD (d-lysergic acid diethylamide) in the therapy of children (a brief review). Abramson HA J. Asthma Res. 5(2), 139-43, (1967)

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[Antagonists of lysergic acid diethylamide (literature review)]. Davydova ON and Kudrin AN Farmakol. Toksikol. 34(5), 629-32, (1971)

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George Harrison's inner light. Oliveira GN, Salgado JV, Barbosa IG, et al. Rev. Bras. Psiquiatr. 34(4), 517-8, (2012)

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Lysergic acid diethylamide. O'Shea B and Fagan J Ir. Med. J. 94(7), 217, (2001)

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Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials. Krebs TS and Johansen PØ J. Psychopharmacol. 26(7), 994-1002, (2012)

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Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties. Shan J, Khelashvili G, Mondal S, et al. PLoS Comput. Biol. 8(4), e1002473, (2012)

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Structural features for functional selectivity at serotonin receptors. Wacker D, Wang C, Katritch V, et al. Science 340(6132), 615-9, (2013)

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Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids. Nelson CC and Foltz RL J. Chromatogr. A 580(1-2), 97-109, (1992)

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The pharmacology of lysergic acid diethylamide: a review. Passie T, Halpern JH, Stichtenoth DO, et al. CNS Neurosci. Ther. 14(4), 295-314, (2008)

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Adverse consequences of lysergic acid diethylamide. Abraham HD and Aldridge AM Addiction 88(10), 1327-34, (1993)

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Determination of buprenorphine, fentanyl and LSD in whole blood by UPLC-MS-MS. Berg T, Jørgenrud B, and Strand DH J. Anal. Toxicol. 37(3), 159-65, (2013)

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Dispersive liquid-liquid microextraction prior to field-amplified sample injection for the sensitive analysis of 3,4-methylenedioxymethamphetamine, phencyclidine and lysergic acid diethylamide by capillary electrophoresis in human urine. Airado-Rodríguez D, Cruces-Blanco C, and García-Campaña AM J. Chromatogr. A 1267, 189-97, (2012)

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Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD). Backstrom JR, Chang MS, Chu H, et al. Biol. Psychiatry 21(2 Suppl), 77S-81S, (1999)

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Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Moreno JL, Holloway T, Umali A, et al. Psychopharmacology 225(1), 217-26, (2013)

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Screening for drugs of abuse (II): Cannabinoids, lysergic acid diethylamide, buprenorphine, methadone, barbiturates, benzodiazepines and other drugs. Simpson D, Braithwaite RA, Jarvie DR, et al. Ann. Clin. Biochem. 34 ( Pt 5), 460-510, (1997)

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Impact of high-pressure processing on vitamin E (α-, γ-, and δ-tocopherol), vitamin D (cholecalciferol and ergocalciferol), and fatty acid profiles in liquid foods. Barba FJ, Esteve MJ, and Frigola A J. Agric. Food Chem. 60(14), 3763-8, (2012)

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Human platelet 5-hydroxytryptamine receptors: binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration. Grahame-Smith DG, Geaney DP, Schachter M, et al. Experientia 44(2), 142-5, (1988)

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Automated high-throughput neurophenotyping of zebrafish social behavior. Green J, Collins C, Kyzar EJ, et al. J. Neurosci. Methods 210(2), 266-71, (2012)

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The removal of bisphenol A from aqueous solutions by MIL-53(Al) and mesostructured MIL-53(Al). Zhou M, Wu YN, Qiao J, et al. J. Colloid. Interface Sci. 405, 157-63, (2013)

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Analysis of lysergic acid amide in human serum and urine after ingestion of Argyreia nervosa seeds. Paulke A, Kremer C, Wunder C, et al. Anal. Bioanal. Chem 404(2), 531-8, (2012)

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Analysis of lysergic acid diethylamide: comparison of capillary electrophoresis with laser-induced fluorescence (CE-LIF) with conventional techniques. Frost M and Köhler H Forensic Sci. Int. 92(2-3), 213-8, (1998)

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LSD in pubic hair in a fatality. Gaulier JM, Maublanc J, Lamballais F, et al. Forensic Sci. Int. 218(1-3), 25-7, (2012)

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Discriminative stimulus effects of N,N-diisopropyltryptamine. Carbonaro TM, Forster MJ, and Gatch MB Psychopharmacology 226(2), 241-6, (2013)

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A pharmacological analysis of processes underlying differential responding: a review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine. Frontali M, Amorico L, De Acetis L, et al. Behav. Biol. 18(1), 1-74, (1976)

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Lysergic acid diethylamide: its effects on human chromosomes nd the human organism in utero. A review of current findings. Titus RJ Int. J. Addict. 7(4), 701-14, (1972)

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Drugs of abuse and benzodiazepines in the Madrid Region (Central Spain): seasonal variation in river waters, occurrence in tap water and potential environmental and human risk. Mendoza A, Rodríguez-Gil JL, González-Alonso S, et al. Environ. Int. 70, 76-87, (2014)

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Recreational use of D-lysergamide from the seeds of Argyreia nervosa, Ipomoea tricolor, Ipomoea violacea, and Ipomoea purpurea in Poland. Juszczak GR and Swiergiel AH J. Psychoactive Drugs 45(1), 79-93, (2013)

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Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Schindler EA, Dave KD, Smolock EM, et al. Pharmacol. Biochem. Behav. 101(1), 69-76, (2012)

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Prevalences of illicit drug use in people aged 50 years and over from two surveys. Fahmy V, Hatch SL, Hotopf M, et al. Age Ageing 41(4), 553-6, (2012)

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Inter-relationship between different platelet measures of 5-HT and their relationship to aggression in human subjects. Marseille R, Lee R, and Coccaro EF Prog. Neuropsychopharmacol. Biol. Psychiatry 36(2), 277-81, (2012)

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Illicit use of LSD or psilocybin, but not MDMA or nonpsychedelic drugs, is associated with mystical experiences in a dose-dependent manner. Lyvers M and Meester M J. Psychoactive Drugs 44(5), 410-7, (2012)

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Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Moreno JL, Holloway T, Rayannavar V, et al. Neurosci. Lett. 536, 69-73, (2013)

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Self-inflicted testicular amputation in first lysergic acid diethylamide use. Blacha C, Schmid MM, Gahr M, et al. J. Addict. Med. 7(1), 83-4, (2013)

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Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex. Schindler EA, Harvey JA, and Aloyo VJ Brain Res. 1491, 98-108, (2013)

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[The substance experience, a history of LSD]. Beck F and Bonnet N Med. Sci. (Paris.) 29(4), 430-3, (2013)

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[Club drugs]. Guerreiro DF, Carmo AL, da Silva JA, et al. Acta Med. Port. 24(5), 739-56, (2011)

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Repression of death consciousness and the psychedelic trip. Dutta V J. Cancer Res. Ther. 8(3), 336-42, (2012)

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D-lysergic acid diethylamide (LSD-25): a survey of the literature. Schwartz M Mil. Med. 132(9), 667-73, (1967)

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The chromosomal and teratogenic effects of lysergic acid diethylamide: a review of the current literature. Smart RG and Bateman K Can. Med. Assoc. J. 99(16), 805-10, (1968)

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Comparative aspects of selected psychoactive compounds: biogenic amines, monoamine oxidase inhibitors, and lysergic acid diethylamide. Pscheidt GR Comp. Biochem. Physiol. 24(1), 249-65, (1968)

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Lysergic acid diethylamide. Louria DB N. Engl. J. Med. 278(8), 435-8, (1968)

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High hopes. Kupferschmidt K Science 345(6192), 18-23, (2014)

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NBOMe - a very different kettle of fish . . . Caldicott DG, Bright SJ, and Barratt MJ Med. J. Aust. 199(5), 322-3, (2013)

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LSD screening in urine performed by CEDIA® LSD assay: positive interference with sertraline. Citterio-Quentin A, Seidel E, Ramuz L, et al. J. Anal. Toxicol. 36(4), 289-90, (2012)

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EFFECT OF LYSERGIC ACID DIETHYLAMIDE ON POTENTIALS EVOKED IN THE SPECIFIC SENSORY PATHWAYS. KEY BJ Br. Med. Bull. 21, 30-5, (1965)

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D-LYSERGIC ACID DIETHYLAMIDE (LSD): A REVIEW OF ITS PRESENT STATUS. HOFFER A Clin. Pharmacol. Ther. 6, 183-255, (1965)

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Merck 14,5634

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