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L7045 Sigma

L 748337 hydrate

≥98% (HPLC)

Synonym: N-(3-{3-[2-(4-Benzenesulfonylamino-phenyl)-ethylamino]-(2S)-2-hydroxy-propoxy}-benzyl)-acetamide hydrate; Acetamide, N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl] hydrate

  • Empirical Formula (Hill Notation) C26H31N3O5S · xH2O

  • Molecular Weight 497.61 (anhydrous basis)

  •  MDL number MFCD20134197

  •  PubChem Substance ID 329817647

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   TYFJHLUOBDKUID-JIDHJSLPSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +4.0 to +8.0°, c = 4 in DMSO
solubility   DMSO: >12 mg/mL
originator   Merck Sharp & Dohme
storage temp.   2-8°C

Description

Biochem/physiol Actions

L 748337 is a selective, competitive beta 3 adrenergic receptor antagonist, that binds to the receptor with an affinity of 04 nM. The affinities for beta-1 and beta-2 receptors are 154 and 204 nM, respectively. The compound potently inhibits agonist-stimulated lipolysis in adipocytes, as well as agonist induced relaxation of smooth muscle.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

β-Adrenoceptors

β-Adrenoceptors are widely distributed, found at both central and peripheral sites, and are activated either via norepinephrine released from sympathetic terminals or via epinephrine (E4250, E4375) r...
Keywords: Antihypertensives, Atomic absorption spectroscopy, Diabetes, Gene expression, Neurotransmitters, Obesity, Reductions, Transduction

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