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L7647 Sigma

Concanavalin A from Canavalia ensiformis (Jack bean)

Type VI, lyophilized powder

Synonym: Con A

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Concanavalin A (Con A), Glycan Recognizing Proteins, Glycobiology,
type   Type VI
form   lyophilized powder
potency   ≤20 μg per mL agglutination activity
impurities   Carbohydrate, essentially free
  salt, essentially free
solubility   water: 1 % (w/v)
storage temp.   −20°C

Description

Analysis Note

Agglutination activity: Determined from serial dilutions of a 1 mg/mL solution (this activity is the lowest conc. to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C). Requires Type A Human Blood.

Biochem/physiol Actions

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Packaging

1 g in poly bottle

25, 100, 250 mg in poly bottle

Preparation Note

Highly purified by specific affinity chromatography.

Price and Availability


Amplified Detection

All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
GK6890000
Protocols & Articles

Articles

Purification of Peroxidase by HPLC on Concanavalin A Coupled to TSKgel® Tresyl-5PW

From our library of Articles, Sigma-Aldrich presents Purification of Peroxidase by HPLC on Concanavalin A Coupled to TSKgel® Tresyl-5PW
Keywords: Chromatography, High performance liquid chromatography, Ligands

Peer-Reviewed Papers
15

References

Related Products

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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