|Related Categories||Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||H2O: >5 mg/mL|
Levetiracetam is a pyrrolidine with antiepileptic activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
|Precautionary statements||P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn|
|Risk Statements (Europe)||22-36|
|Safety Statements (Europe)||26|
Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy. Phabphal K, Geater A, Limapichat K, et al. Epilepsia 54(6), e94-8, (2013)
Ineffectiveness of topiramate and levetiracetam in infantile spasms non-responsive to steroids. Open labeled randomized prospective study. Mahmoud AA, Rizk TM, Mansy AA, et al. Neurosciences (Riyadh.) 18(2), 143-6, (2013)
A prospective multicenter comparison of levetiracetam versus phenytoin for early posttraumatic seizure prophylaxis. Inaba K, Menaker J, Branco BC, et al. J. Trauma Acute Care Surg. 74(3), 766-71; discussion 771-3, (2013)
Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre. Steinhoff BJ, Maren Staack A, and Wisniewski I Epileptic Disord. 14(4), 379-87, (2012)
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. Maschio M, Dinapoli L, Sperati F, et al. Epileptic Disord. 14(4), 388-97, (2012)
Reduced immunoglobulin levels in epilepsy patients treated with levetiracetam, lamotrigine, or carbamazepine. Svalheim S, Mushtaq U, Mochol M, et al. Acta Neurol. Scand.,. Suppl.c. (196), 11-5, (2013)
The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model. Stepanović-Petrović RM, Micov AM, Tomić MA, et al. Anesth. Analg. 115(6), 1457-66, (2012)
Drug-drug interaction between methotrexate and levetiracetam in a child treated for acute lymphoblastic leukemia. Parentelli AS, Phulpin-Weibel A, Mansuy L, et al. Pediatr. Blood Cancer 60(2), 340-1, (2013)
Levetiracetam versus carbamazepine in patients with late poststroke seizures: a multicenter prospective randomized open-label study (EpIC Project). Consoli D, Bosco D, Postorino P, et al. Cerebrovasc. Dis. 34(4), 282-9, (2012)
Effects of levetiracetam on seizure frequency and neuropsychological impairments in children with refractory epilepsy with secondary bilateral synchrony. Kanemura H, Sano F, Sugita K, et al. Seizure 22(1), 43-7, (2013)
Inhibitory effects of levetiracetam on the high-voltage-activated L-type Ca²⁺ channels in hippocampal CA3 neurons of spontaneously epileptic rat (SER). Yan HD, Ishihara K, Seki T, et al. Brain Res. Bull. 90, 142-8, (2013)
Successful treatment of POLG-related mitochondrial epilepsy with antiepileptic drugs and low glycaemic index diet. Martikainen MH, Päivärinta M, Jääskeläinen S, et al. Epileptic Disord. 14(4), 438-41, (2012)
[Dynamics of cognitive and emotional-volitional disorders in children and adolescents with refractory epilepsy during the treatment with levetiracetam]. Popov IuV and Iakovleva IuA Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 113(5 Pt 2), 48-52, (2013)
Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. Bjørnæs H, Bakke KA, Larsson PG, et al. Epilepsy Behav. 27(1), 40-8, (2013)
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