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L9133 Sigma

Leucine Enkephalin acetate salt hydrate

≥95% (HPLC)

  • Empirical Formula (Hill Notation) C28H37N5O7 · xC2H4O2 · yH2O

  • Molecular Weight 555.62 (anhydrous free base basis)

  •  MDL number MFCD11045938

  •  PubChem Substance ID 329817669

  •  eCl@ss 32160409

  • Popular Documents:  Specification Sheet (PDF)  

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enkephalins, Neuropeptides, Opioid Peptides,
InChI Key   QKDIOZBQOQJXFR-XQCXOTTHSA-N
assay   ≥95% (HPLC)
storage temp.   −20°C
Gene Information   human ... OPRD1(4985), OPRM1(4988)
mouse ... OPRD1(18386), OPRM1(18390)
rat ... OPRD1(24613), OPRM1(25601)

Description

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu

Application

Leucine Enkephalin acetate salt hydrate has been used in liquid chromatography-mass spectrometry (LCMS)/MS for calibration of the system and for relative correction of the spectra.

Biochem/physiol Actions

Endogenous opioid neurotransmitter/neuromodulator that is an agonist at μ and δ opioid receptors; localization in brain parallels the localization of δ receptors.

Leucine Enkephalin (LEU-ENK) functions as agonists at both μ- and δ-opioid receptor sites. It might also play a role as neurotransmitter agent at morphine-sensitive synapses. Leucine Enkephalin is also associated with pain regulation. LEU-ENK expressed in camel lacrimal nerve regulates lacrimal fluid and protein secretion. LEU-ENK is degraded during metabolism by several enzymes, including aminopeptidase-N (APN), neutral endopeptidase (NEP), dipeptidyl peptidase- 3 (DPP3), carboxy peptidase-A6 (CPA-6) and angiotensin converting enzyme (ACE), which are sometimes referred to as enkephalinases.

General description

Leucine Enkephalin is a pentapeptide and is a normal component of central and peripheral tissues. Leucine Enkephalin has amino acid sequence Tyr-Gly-Gly-Phe-Leu and is distributed in the brains of many animals, including humans.

Price and Availability


Amplified Detection

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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