|Related Categories||Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants, Aspalathus linearis (Rooibos tea), Bioactive Small Molecules, Cancer Metabolism,|
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), GSK3A(2931)|
mouse ... Hexa(15211)
rat ... Il4(287287), Tnf(24835)
Hydroxylated flavone derivative, a strong antioxidant and radical scavenger. Suggested to play a role in prevention of cancer, possibly via the inhibition of fatty acid synthase activity.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26|
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
BioFiles 2007, 2.2, 2.
Keywords: Adhesion, Anti-inflammatory agents, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins
Proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sour...
Keywords: Apoptosis, Cancer, Carboxylations, Catalysis, Gene expression, Glycolysis, Metabolism, Oxidations, PAGE, Phosphorylations
Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, Sigma® Life Science and Chloe McClanahan, Product Manager, Sigma Life Science
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical
Autocrine TNF-α-mediated NF-κB activation is a determinant for evasion of CD40-induced cytotoxicity in cancer cells. Li D, Zhong Y, Zhou Y, et al. Biochem. Biophys. Res. Commun. 436(3), 467-72, (2013)
Interspecies difference of luteolin and apigenin after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics. Li LP, Wu XD, Chen ZJ, et al. Pharmazie 68(3), 195-200, (2013)
The Passiflora tripartita (Banana Passion) fruit: a source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC–DAD–ESI/MS/MS. Simirgiotis MJ, Schmeda-Hirschmann G, Bórquez J, et al. Molecules 18(2), 1672-92, (2013)
Luteolin induced-growth inhibition and apoptosis of human esophageal squamous carcinoma cell line Eca109 cells in vitro. Wang TT, Wang SK, Huang GL, et al. Asian Pac. J. Cancer Prev. 13(11), 5455-61, (2012)
Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Pratheeshkumar P, Son YO, Budhraja A, et al. PLoS ONE 7(12), e52279, (2012)
Centipede grass exerts anti-adipogenic activity through inhibition of C/EBPβ, C/EBPα, and PPARγ expression and the AKT signaling pathway in 3T3-L1 adipocytes. Park HJ, Chung BY, Lee MK, et al. BMC Complement Altern. Med. 12, 230, (2012)
Luteolin inhibits angiotensin II-induced human umbilical vein endothelial cell proliferation and migration through downregulation of Src and Akt phosphorylation. Zhu M, Chen D, Li D, et al. Circ. J. 77(3), 772-9, (2013)
Synergistic activity of luteolin and amoxicillin combination against amoxicillin-resistant Escherichia coli and mode of action. Eumkeb G, Siriwong S, and Thumanu K J. Photochem. Photobiol. B, Biol. 117, 247-53, (2012)
UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. Yin R, Han F, Tang Z, et al. J. Pharm. Biomed. Anal. 72, 127-33, (2013)
A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS. Quirantes-Piné R, Zurek G, Barrajón-Catalán E, et al. J. Pharm. Biomed. Anal. 72, 121-6, (2013)
Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. Verschooten L, Barrette K, Van Kelst S, et al. PLoS ONE 7(10), e48264, (2012)
Anti-angiogenic effect of luteolin on retinal neovascularization via blockade of reactive oxygen species production. Park SW, Cho CS, Jun HO, et al. Invest. Ophthalmol. Vis. Sci. 53(12), 7718-26, (2012)
Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Lupu, R., and Menendez, J.A. Curr. Pharm. Biotechnol. 7, 483-493, (2006)
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa. Hisashi Matsuda et al Bioorg. Med. Chem. 15, 1539-46, (2007)
Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Andrei I Khlebnikov et al Bioorg. Med. Chem. 15, 1749-70, (2007)
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors. Srinivas Kantevari et al Bioorg. Med. Chem. 19, 4772-81, (2011)
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