|Related Categories||Ricinus communis (Castor bean), Bioactive Small Molecules, Cell Biology, Glycan Recognizing Proteins, Glycobiology,|
|form||buffered aqueous glycerol solution|
|potency||≥250 μg/mL per mL agglutination activity|
|composition||Protein, ≥0.3 mg/mL Lowry-TCA|
Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 7.2, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hour incubation at 25°C.
Ricin A chain inactivates the 60 S ribosomal subunit of eukaryotic cells, inhibiting protein synthesis. This toxic activity is independent of the presence of the B chain of ricin.
Ricinus communis toxin (also named RCA60, RCAII, Ricin D, or RCL III) is a highly toxic protein, mol. wt. ~60 kDa, composed of two chains, A and B, connected by a single disulfide bridge.
Purified by affinity chromatography.
Electrophoretically pure (SDS-PAGE)
Solution in 40% glycerol containing 10 mM phosphate, pH 6.0, 0.15 M NaCl, 10 mM galactose and 0.5 mM dithioerythritol
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buffered aqueous solution
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Reactivity: Anti-Ricin β-chains
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P260-P264-P280-P284-P301 + P310-P302 + P350|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||26/27/28-42/43|
|Safety Statements (Europe)||23-28-36/37-45|
|RIDADR||UN 3172 6.1 / PGIII|
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